Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131, Padova, Italy.
Current address: Department of Chemistry, The Pennsylvania State University, University Park, PA, USA.
Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1611-1615. doi: 10.1002/anie.201711964. Epub 2018 Jan 12.
The transient activation of function using chemical fuels is common in nature, but much less in synthetic systems. Progress towards the development of systems with a complexity similar to that of natural ones requires chemical fuel selectivity. Here, we show that a self-assembled nanosystem, composed of monolayer-protected gold nanoparticles and a fluorogenic peptide, is activated for transient signal generation only in case the chemical fuel matches the recognition site present at the nanoparticle surface. A modification of the recognition site in the nanosystem completely changes the chemical fuel selectivity. When two nanosystems are simultaneously present, the selectivity expressed by the system depends on the concentration of nucleotide added.
利用化学燃料实现功能的瞬时激活在自然界中很常见，但在合成系统中却很少见。要想开发出具有类似于自然系统的复杂程度的系统，就需要具有化学燃料选择性。在这里，我们展示了一个由单层保护的金纳米粒子和一个荧光肽组成的自组装纳米系统，只有当化学燃料与纳米粒子表面的识别位点匹配时，该纳米系统才会被激活以产生瞬时信号。纳米系统中识别位点的修饰完全改变了化学燃料的选择性。当同时存在两个纳米系统时，系统表达的选择性取决于添加的核苷酸浓度。
