van Veen S, Aarnoudse-Moens C S H, Oosterlaan J, van Sonderen L, de Haan T R, van Kaam A H, van Wassenaer-Leemhuis A G
Department of Neonatology, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands.
Department of Neonatology, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands; Psychosocial Department, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands; Clinical Neuropsychology Section, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Early Hum Dev. 2018 Feb;117:39-43. doi: 10.1016/j.earlhumdev.2017.12.010. Epub 2017 Dec 21.
To explore changes in motor and cognitive outcomes in very preterm (VP; gestational age<30weeks) born children between ages five and six years, and to determine whether changes in these outcomes were associated with the use of healthcare therapies and educational provisions.
Single-center observational cohort study. Five-year-old VP born children of a one-year-cohort of our neonatal follow-up program (N=90) were invited for re-assessments at age six. Use of healthcare therapies and educational provisions was registered at ages five and six years. Motor function (Movement Assessment Battery for Children-2 [M-ABC-2]; higher scores indicate better functioning) and IQ (Wechsler Preschool and Primary Scale for Intelligence [WPPSI-III-NL]) were assessed at both ages.
Sixty-four VP born children were seen at ages five and at six years. In this year, 61% received healthcare therapies and/or educational provisions. M-ABC-2 scores of VP born children who received healthcare therapy and/or educational provisions were significantly higher (M=8.9 [SD=3.2]) at age six years than at age five years (M=7.5 [SD=3.3]); p<0.00). M-ABC-2 scores remained stable in the average range in VP born children without any support. IQ scores remained stable irrespective of received support.
Improvements in motor outcomes are associated with the use of healthcare therapies and/or educational support between ages five and six years in VP born children. Future studies need to determine the efficacy of existing interventions, and to develop tailored interventions to support VP born children in the transfer period from preschool to primary education.
探讨极早产儿（孕周<30周）在5至6岁时运动和认知结果的变化，并确定这些结果的变化是否与医疗保健治疗和教育措施的使用有关。
单中心观察性队列研究。邀请了我们新生儿随访项目一年队列中的90名5岁极早产儿在6岁时进行重新评估。记录5岁和6岁时医疗保健治疗和教育措施的使用情况。在两个年龄段均评估运动功能（儿童运动评估量表第二版[M-ABC-2]；分数越高功能越好）和智商（韦氏学前和小学智力量表[WPPSI-III-NL]）。
64名极早产儿在5岁和6岁时接受了检查。在这一年中，61%的儿童接受了医疗保健治疗和/或教育措施。接受医疗保健治疗和/或教育措施的极早产儿在6岁时的M-ABC-2分数（M=8.9[标准差=3.2]）显著高于5岁时（M=7.5[标准差=3.3]）；p<0.00）。在没有任何支持的极早产儿中，M-ABC-2分数在平均范围内保持稳定。无论是否接受支持，智商分数都保持稳定。
极早产儿在5至6岁期间运动结果的改善与医疗保健治疗和/或教育支持的使用有关。未来的研究需要确定现有干预措施的疗效，并制定针对性的干预措施，以支持极早产儿从学前教育到小学教育的过渡阶段。
