Naus C C
Department of Anatomy, University of Western Ontario, London, Canada.
Neurosci Lett. 1989 Jan 16;96(2):133-9. doi: 10.1016/0304-3940(89)90046-3.
Using antisera directed against somatostatin-28 or somatostatin-28(1-12), the development of somatostatin-like immunoreactivity (SS-LI) was examined in the hippocampal formation of normal and reeler mice. As early as postnatal day 5, SS-labeled neurons exhibit the adult pattern of distribution in the normal hippocampal formation, these neurons being situated predominantly in the stratum oriens of the hippocampus and the hilus of the dentate gyrus. In contrast, SS-labeled neurons in the reeler hippocampal formation are dispersed throughout the various layers, reflecting the disrupted laminar organization of the hippocampus in this mutant. In both the normal and reeler hippocampal formation, SS-labeled fibers are most abundant in the stratum lacunosum moleculare. However, in the reeler, there appears to be increase in the density of SS-LI fibers, not only in the stratum lacunosum moleculare but also in the stratum oriens, stratum radiatum and pyramidal cell layer of the hippocampus.
利用针对生长抑素 - 28或生长抑素 - 28(1 - 12)的抗血清，研究了正常和reeler小鼠海马结构中生长抑素样免疫反应性（SS - LI）的发育情况。早在出生后第5天，正常海马结构中SS标记的神经元就呈现出成年期的分布模式，这些神经元主要位于海马的原层和齿状回的门区。相比之下，reeler海马结构中SS标记的神经元分散在各层，反映出该突变体中海马分层组织的紊乱。在正常和reeler海马结构中，SS标记的纤维在分子层最丰富。然而，在reeler小鼠中，不仅分子层，而且海马的原层、放射层和锥体细胞层中，SS - LI纤维的密度似乎都有所增加。
