含 GABA 的脂质体：针对神经疾病的神经科学应用和转化视角。
GABA-containing liposomes: neuroscience applications and translational perspectives for targeting neurological diseases.
机构信息
Department of Physiology & Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Department of Physiology & Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
出版信息
Nanomedicine. 2018 Apr;14(3):781-788. doi: 10.1016/j.nano.2017.12.007. Epub 2017 Dec 24.
There are multiple challenges for neuropharmacology in the future. Undoubtedly, one of the greatest challenges is the development of strategies for pharmacological targeting of specific brain regions for treatment of diseases. GABA is the main inhibitory neurotransmitter in the central nervous system, and dysfunction of GABAergic mechanisms is associated with different neurological conditions. Liposomes are lipid vesicles that are able to encapsulate chemical compounds and are used for chronic drug delivery. This short review reports our experience with the development of liposomes for encapsulation and chronic delivery of GABA to sites within the brain. Directions for future research regarding the efficacy and practical use of GABA-containing liposomes for extended periods of time as well as understanding and targeting neurological conditions are discussed.
神经药理学未来面临多重挑战。毫无疑问，最大的挑战之一是开发针对特定脑区的药理学靶向策略，以治疗疾病。GABA 是中枢神经系统中的主要抑制性神经递质，GABA 能机制功能障碍与多种神经疾病有关。脂质体是能够包裹化合物的脂质囊泡，用于慢性药物递送。本综述报告了我们开发脂质体用于 GABA 包封和慢性脑内递送至特定部位的经验。讨论了 GABA 脂质体在延长时间内的疗效和实际应用，以及理解和靶向神经疾病方面的未来研究方向。
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