Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 N. University, Ann Arbor, MI 48109, USA.
Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 N. University, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, 830 N. University, Ann Arbor, MI 48109, USA.
Curr Opin Struct Biol. 2018 Feb;48:117-123. doi: 10.1016/j.sbi.2017.12.003. Epub 2017 Dec 23.
Recently, several innovative approaches have been developed that allow one to directly screen or select for improved protein folding in the cellular context. These methods have the potential of not just leading to a better understanding of the in vivo folding process, they may also allow for improved production of proteins of biotechnological interest.
最近，已经开发出了几种创新的方法，可以直接在细胞环境中筛选或选择改善蛋白质折叠的方法。这些方法不仅有可能更好地了解体内折叠过程，还可能允许提高生物技术感兴趣的蛋白质的生产。
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