Boothe James T, Budd G Thomas, Smolkin Matthew B, Ma Patrick C
WVU Cancer Institute, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, USA.
WVU School of Medicine, West Virginia University, Morgantown, West Virginia, USA.
Case Rep Oncol. 2017 Nov 13;10(3):998-1005. doi: 10.1159/000484041. eCollection 2017 Sep-Dec.
Solitary fibrous tumor of the pleura is a rare and usually benign primary neoplasm arising from mesenchymal cells of the submesothelial tissue. We present here the case of a patient diagnosed with CD34-positive advanced malignant solitary fibrous tumor of the pleura whose disease failed to respond to combination cytotoxic chemotherapy agents, but demonstrated a prompt near-complete response to checkpoint blockade treatment using the anti-programmed death (PD)-1 monoclonal antibody pembrolizumab, based on tumor molecular profiling revealing tumoral expression positivity for both programmed death-ligand 1 (PD-L1) and PD-1. The patient experienced minimal adverse effects from the treatment with durable favorable response lasting up to cycle 26.
胸膜孤立性纤维瘤是一种罕见的、通常为良性的原发性肿瘤，起源于间皮下组织的间充质细胞。我们在此报告一例被诊断为CD34阳性的晚期恶性胸膜孤立性纤维瘤患者，其疾病对联合细胞毒性化疗药物无反应，但基于肿瘤分子谱显示程序性死亡配体1（PD-L1）和程序性死亡（PD）-1均呈肿瘤表达阳性，使用抗程序性死亡（PD）-1单克隆抗体帕博利珠单抗进行检查点阻断治疗后显示出迅速的近完全缓解。该患者治疗的不良反应极小，持续至第26周期仍有持久的良好反应。
