Wang Xinyang, Wrigley Tim V, Bennell Kim L, Wang Yuanyuan, Fortin Karine, Cicuttini Flavia M, Lloyd David G, Bryant Adam L
Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, Exercise and Sports Medicine, School of Health Sciences, The University of Melbourne, 161 Barry Street, Carlton, Melbourne, Victoria, 3010, Australia.
Department of Orthopedic Surgery, Beijing Chao-Yang Hospital, Beijing, China.
J Orthop Res. 2018 Jul;36(7):2022-2029. doi: 10.1002/jor.23846. Epub 2018 Jan 24.
Cartilage T2 relaxation time in isolated anterior cruciate ligament reconstruction (ACLR) without concomitant meniscal pathology and their changes over time remain unclear. The purpose of this exploratory study was to: (i) compare cartilage T2 relaxation time (T2 values) in people with isolated ACLR at 2-3 years post-surgery (baseline) and matched healthy controls and; (ii) evaluate the subsequent 2-year change in T2 values in people with ACLR. Twenty-eight participants with isolated ACLR and nine healthy volunteers underwent knee magnetic resonance imaging (MRI) at baseline; 16 ACLR participants were re-imaged 2 years later. Cartilage T2 values in full thickness, superficial layers, and deep layers were quantified in the tibia, femur, trochlear, and patella. Between-group comparisons at baseline were performed using analysis of covariance adjusting for age, sex, and body mass index. Changes over time in the ACLR group were evaluated using paired sample t-tests. ACLR participants showed significantly higher (p = 0.03) T2 values in the deep layer of medial femoral condyle at baseline compared to controls (mean difference 4.4 ms [13%], 95%CI 0.4, 8.3 ms). Over 2 years, ACLR participants showed a significant reduction (p = 0.04) in T2 value in the deep layer of lateral tibia (mean change 1.4 ms [-7%], 95%CI 0.04, 2.8 ms). The decrease in T2 values suggests improvement in cartilage composition in the lateral tibia (deep layer) of ACLR participants. Further research with larger ACLR cohorts divided according to meniscal status and matched healthy cohorts are needed to further understand cartilage changes post-ACLR. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2022-2029, 2018.
在不伴有半月板病变的单纯前交叉韧带重建术（ACLR）中，软骨的T2弛豫时间及其随时间的变化尚不清楚。本探索性研究的目的是：（i）比较单纯ACLR患者术后2 - 3年（基线）与匹配的健康对照者的软骨T2弛豫时间（T2值）；（ii）评估ACLR患者T2值在随后2年的变化。28例单纯ACLR患者和9名健康志愿者在基线时接受了膝关节磁共振成像（MRI）检查；16例ACLR患者在2年后再次进行成像。对胫骨、股骨、滑车和髌骨的全层、表层和深层软骨T2值进行了量化。在基线时，使用协方差分析对年龄、性别和体重指数进行调整后进行组间比较。使用配对样本t检验评估ACLR组随时间的变化。与对照组相比，ACLR患者在基线时股骨内侧髁深层的T2值显著更高（p = 0.03）（平均差异4.4 ms [13%]，95%CI 0.4，8.3 ms）。在2年的时间里，ACLR患者胫骨外侧深层的T2值显著降低（p = 0.04）（平均变化1.4 ms [-7%]，95%CI 0.04，2.8 ms）。T2值的降低表明ACLR患者胫骨外侧（深层）软骨成分有所改善。需要对更大的ACLR队列根据半月板状态进行分组，并与匹配的健康队列进行进一步研究，以进一步了解ACLR术后的软骨变化。© 2017骨科研究协会。由威利期刊公司出版。《矫形外科学研究》36:2022 - 2029，2018。
