Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA; Arthritis Clinic and Research Center, Peking University People's Hospital, Beijing, China.
Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Osteoarthritis Cartilage. 2019 Jun;27(6):915-921. doi: 10.1016/j.joca.2019.01.017. Epub 2019 Feb 23.
(1) To identify bone-shape changes from baseline to 3-years after anterior cruciate ligament reconstruction (ACLR). (2) to assess association between changes in bone-shape from baseline to 6-months and changes in cartilage matrix and patient functions and symptoms from baseline to 3-years after ACLR.
Bilateral knees of 30 patients with unilateral ACL injuries were scanned at baseline, 6-months, 1-, 2-, and 3-years after ACLR. Bilateral knees of 13 controls were scanned at baseline, 1- and 3-years. Mean T1ρ and T2 values of each cartilage compartment were computed. Bone shape was quantified using statistical shape modeling (SSM) and 3D-MRI. Patient functions and symptoms were evaluated using Knee Injury and Osteoarthritis Outcome Score (KOOS).
Statistically significant changes were observed in Femur 2 (medial femoral condyle [MF] shape), Femur 6 (intercondylar notch width), Tibia 1 (tibia plateau area), and Tibia 7 (medial tibia slope) over 3-years after ACLR. Statistically significant differences were observed between injured and control knees in several modes. Statistically significant correlations were found between changes in bone shape (ΔFemur 6, ΔFemur 8 [trochlea inclination and MF height], ΔTibia 1) from baseline to 6-months and that of cartilage T1ρ and T2 and KOOS from baseline to 3-years after ACLR.
Bone shape remodeling occurs after ACLR, and early bone shape changes (within 6 months) correlated with cartilage matrix and patient outcomes at 3-years after ACLR. Bone shape can be a promising imaging biomarker that stratifies patients at high risk for post-traumatic osteoarthritis (PTOA).
(1) 从基线到前交叉韧带重建 (ACLR) 后 3 年，识别骨形状变化。(2) 评估基线至 ACLR 后 6 个月的骨形状变化与基线至 3 年的软骨基质和患者功能及症状变化之间的相关性。
30 例单侧 ACL 损伤患者的双侧膝关节在基线、6 个月、1、2 和 3 年时进行扫描。13 例对照患者的双侧膝关节在基线、1 年和 3 年时进行扫描。计算每个软骨间隔的平均 T1ρ 和 T2 值。使用统计形状建模 (SSM) 和 3D-MRI 量化骨形状。使用膝关节损伤和骨关节炎结果评分 (KOOS) 评估患者的功能和症状。
在 ACLR 后 3 年，股骨 2（内侧股骨髁 [MF] 形状）、股骨 6（髁间切迹宽度）、胫骨 1（胫骨平台面积）和胫骨 7（内侧胫骨斜率）发生了统计学上显著的变化。在多个模式中观察到受伤和对照膝关节之间存在统计学显著差异。在基线至 6 个月和基线至 ACLR 后 3 年的骨形状（Δ股骨 6、Δ股骨 8 [滑车倾斜和 MF 高度]、Δ胫骨 1）变化与软骨 T1ρ 和 T2 以及 KOOS 之间存在统计学显著相关性。
ACL 重建后发生骨形状重塑，早期骨形状变化（6 个月内）与 ACLR 后 3 年的软骨基质和患者结局相关。骨形状可能是一种有前途的影像学生物标志物，可对创伤后骨关节炎（PTOA）高危患者进行分层。
