多供应商多部位定量 MRI 分析前交叉韧带重建后 10 年的软骨退变：MOON-MRI 方案及初步结果。
Multi-vendor multi-site quantitative MRI analysis of cartilage degeneration 10 Years after anterior cruciate ligament reconstruction: MOON-MRI protocol and preliminary results.
机构信息
Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
出版信息
Osteoarthritis Cartilage. 2022 Dec;30(12):1647-1657. doi: 10.1016/j.joca.2022.08.006. Epub 2022 Aug 30.
OBJECTIVE
To describe the protocol of a multi-vendor, multi-site quantitative MRI study for knee post-traumatic osteoarthritis (PTOA), and to present preliminary results of cartilage degeneration using MR T and T imaging 10 years after anterior cruciate ligament reconstruction (ACLR).
DESIGN
This study involves three sites and two MR platforms. The patients are from a nested cohort (termed as Onsite cohort) within the Multicenter Orthopaedic Outcomes Network (MOON) cohort 10 years after ACLR. Phantoms and controls were scanned for evaluating reproducibility. Cartilage was automatically segmented, and T and T were compared between operated, contralateral, and control knees.
RESULTS
Sixty-eight ACL-reconstructed patients and 20 healthy controls were included. In phantoms, the intra-site coefficients of variation (CVs) of repeated scans ranged 1.8-2.1% for T and 1.3-1.7% for T. The inter-site CVs ranged 1.6-2.1% for T and 1.1-1.4% for T. In human subjects, the intra-site scan/rescan CVs ranged 2.2-3.5% for T and 2.6-4.9% for T for the six major compartments. In patients, operated knees showed significantly higher T and T values mainly in medial femoral condyle, medial tibia and trochlear cartilage compared with contralateral knees, and showed significantly higer T and T values in all six compartments compared to healthy control knees. The patient contralateral knees showed higher T and T values mainly in the lateral femoral condyle, lateral tibia, trochlear, and patellar cartilage compared to healthy control knees.
CONCLUSION
A platform and workflow with rigorous quality control has been established for a multi-vendor multi-site quantitative MRI study in evaluating PTOA 10 years after ACLR. Our preliminary report suggests significant cartilage matrix changes in both operated and contralateral knees compared with healthy control knees.
目的
描述一项多厂商、多地点定量 MRI 研究膝关节创伤后骨关节炎（PTOA）的方案，并展示前交叉韧带重建（ACLR）后 10 年使用 MR T1 和 T2 成像评估软骨退变的初步结果。
设计
本研究涉及三个地点和两个 MRI 平台。患者来自 MOON 队列中嵌套队列（称为 Onsite 队列），这是 ACLR 后 10 年的研究对象。扫描了体模和对照者以评估可重复性。对软骨进行自动分割，并比较了手术侧、对侧和对照侧膝关节的 T1 和 T2 值。
结果
纳入了 68 例 ACL 重建患者和 20 名健康对照者。在体模中，重复扫描的同部位内变异系数（CV）范围为 T1 的 1.8-2.1%和 T2 的 1.3-1.7%。不同部位的 CV 范围为 T1 的 1.6-2.1%和 T2 的 1.1-1.4%。在人体中，同部位扫描/重扫的 CV 范围为 T1 的 2.2-3.5%和 T2 的 2.6-4.9%，这六个主要部位均是如此。在患者中，与对侧膝关节相比，手术侧膝关节的 T1 和 T2 值主要在股骨内侧髁、胫骨内侧和滑车软骨中显著升高，与健康对照膝关节相比，所有六个部位的 T1 和 T2 值均显著升高。患者的对侧膝关节与健康对照膝关节相比，T1 和 T2 值主要在股骨外侧髁、胫骨外侧、滑车和髌骨软骨中升高。
结论
已经建立了一个具有严格质量控制的平台和工作流程，用于评估 ACLR 后 10 年 PTOA 的多厂商、多地点定量 MRI 研究。我们的初步报告表明，与健康对照膝关节相比，手术侧和对侧膝关节的软骨基质均发生了显著变化。
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