Angarita Dávila Lissé, Durán Agüero Samuel, Apaicio Daniel, Parra Karla, Uzcátegui Maria, Céspedes Virginia, Reina Villasmil Nadia, López Miranda José
Carrera de Nutrición y Dietética, Facultad de Medicina, Concepción-Talcahuano, Chile, Universidad Andres Bello.
Nutr Hosp. 2017 Nov 16;34(5):1455-1462. doi: 10.20960/nh.1153.
Currently the food industry has generated interest in non-nutritive sweeteners, for example Stevia and in special components such as L-carnitine, used in formulations of nutritional supplements for glycemic control specific for diabetics. The present study evaluated the effect of stevia and L-carnitine on the glycemic index (GI) and glycemic load (CG) of a nutritional supplement in 19 healthy subjects (9 men and 10 women), who randomly completed 3 consumption tests, 1 for the supplement and 1 for each reference product: Glucose solution (SG) and white bread (PB), obtaining blood samples at the 0, 15, 30, 45, 60, 90 and 120 min times; for measurement of blood glucose, basal and postprandial insulin. The increase area under the glucose curve (IAUC) was lower for supplement 11,778.73 than for reference products (SG) 13,724.06; (PB) 13,153.56 α= p 0.005. IG = (62) and CG = (16) were intermediate and lower than white bread IG = (69) and CG = (18), with no difference in postprandial insulin. This demonstrates that this nutritional supplement formulated with stevia and L-carnitine is able to prolong the glycemic response without increasing the insulin requirements in healthy subjects. Specific studies are required in diabetics to validate whether the glycemic impact is lower than the standard product. The presence of other nutrients in the formula, influential in these indicators, does not allow to infer that the results are due only to the type of sweetener used and the L-carnitine.
目前，食品行业对非营养性甜味剂产生了兴趣，例如甜菊糖苷，以及对特殊成分如左旋肉碱也很感兴趣，左旋肉碱用于糖尿病患者血糖控制的营养补充剂配方中。本研究评估了甜菊糖苷和左旋肉碱对19名健康受试者（9名男性和10名女性）营养补充剂的血糖指数（GI）和血糖负荷（GL）的影响，这些受试者随机完成3次消费测试，1次针对补充剂，1次针对每种参考产品：葡萄糖溶液（SG）和白面包（PB），在0、15、30、45、60、90和120分钟时采集血样；用于测量血糖、基础胰岛素和餐后胰岛素。补充剂的葡萄糖曲线下面积增加（IAUC）为11,778.73，低于参考产品（SG）的13,724.06；（PB）的13,153.56，α = p 0.005。补充剂的血糖指数（IG） = （62）和血糖负荷（CG） = （16）处于中等水平且低于白面包的血糖指数（IG） = （69）和血糖负荷（CG） = （18），餐后胰岛素无差异。这表明这种用甜菊糖苷和左旋肉碱配制的营养补充剂能够延长血糖反应，而不会增加健康受试者的胰岛素需求。需要对糖尿病患者进行具体研究，以验证其血糖影响是否低于标准产品。配方中其他营养素的存在对这些指标有影响，因此不能推断结果仅归因于所使用的甜味剂类型和左旋肉碱。
