Angarita Dávila Lissé, López Miranda José, Aparicio Camargo Daniel, Parra Zuleta Karla, Uzcátegui González Maria, Céspedes Nava Virginia, Durán Agüero Samuel, Reyna Villasmil Nadia
Escuela de Nutrición y Dietética, Facultad de Medicina, Chile, Universidad Andrés Bello.
Nutr Hosp. 2017 Jun 5;34(3):532-539. doi: 10.20960/nh.654.
Objective: The aim of this study is to compare the glycemic index (GI) and glycemic load (GL) of two formulas with the same glucose content with different sweeteners and dietary fiber for diabetics in healthy adults and in patients with type-2 diabetes (DM2). Methodology: In this randomized, double-blind crossover research, eleven healthy people and six with DM2 consumed two enteral formulas, Glucerna SR®, Laboratorios Abbott C.A. (GF) and Enterex Diabetic®, Victus C.A. (EF), sweetened with fructose y sucralose, with 1.2 and 1.3 g/100 ml of fiber source respectively (four times). Additionally, they consumed glucose solution once, obtaining blood samples at 0, 15, 30, 45, 60, 90 and 120 min for controls; in the diabetics, minutes 150 and 180 were added for measuring blood glucose, basal and postprandial insulin after two and three hours. Results: The incremental area under the curve (IAUC) was lower for the formulas rather than for SG. In the healthy controls was 12,857 ± 422 for EF and 11,601 ± 272 for GF (p < 0.014). In diabetics, this curve reduced for GF (28,656 ± 123) compared to EF (29,855 ± 496) (p < 0.01). The IG resulted in 58.07 ± 8.4 and 60.7 ± 2 for GF and EF, respectively, in the controls, and 65.16 ± 0.2 and 68.06 ± 1 in diabetics, without significant differences, as well as in post-prandial insulin. Conclusions: The GI and the GL of the two formulas resulted in an intermediate value in both groups, with a glycemic profile inferior to SG. No significant differences were observed regarding insulin behavior, showing that the absorption rate of carbohydrates in these formulas is slower, with a lower glycemic impact than the pattern product; thus, making its indication acceptable for the diabetic patient.
本研究旨在比较两种葡萄糖含量相同但甜味剂和膳食纤维不同的配方产品，对健康成年人及2型糖尿病（DM2）患者的血糖指数（GI）和血糖负荷（GL）。方法：在这项随机、双盲交叉研究中，11名健康人和6名DM2患者食用了两种肠内配方产品，分别是雅培实验室公司（Laboratorios Abbott C.A.）的益力佳SR（Glucerna SR®）（GF）和维图斯公司（Victus C.A.）的安素益力佳糖尿病专用营养配方（Enterex Diabetic®）（EF），它们分别用果糖和三氯蔗糖调味，膳食纤维含量分别为1.2 g/100 ml和1.3 g/100 ml（食用四次）。此外，他们还饮用了一次葡萄糖溶液，并在0、15、30、45、60、90和120分钟采集血样用于对照；对于糖尿病患者，在两小时和三小时后增加150分钟和180分钟用于测量血糖、基础胰岛素和餐后胰岛素。结果：配方产品的曲线下增量面积（IAUC）低于葡萄糖。在健康对照组中，EF的IAUC为12,857±422，GF为11,601±272（p<0.014）。在糖尿病患者中，GF的该曲线（28,656±123）比EF（29,855±496）降低（p<0.01）。在对照组中，GF和EF的IG分别为58.07±8.4和60.7±2，在糖尿病患者中分别为65.16±0.2和68.06±1，无显著差异，餐后胰岛素情况也无显著差异。结论：两种配方产品的GI和GL在两组中均处于中间值，血糖情况低于葡萄糖。在胰岛素行为方面未观察到显著差异，表明这些配方产品中碳水化合物的吸收率较慢，血糖影响低于对照产品；因此，其适用于糖尿病患者。
