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腹壁成形术风险计算器的开发与内部验证

Development and Internal Validation of the Abdominoplasty Risk Calculator.

作者信息

Vu Michael M, Ellis Marco F, Blough Jordan T, Gutowski Karol A, Kim John Y S

机构信息

Chicago, Ill.

From the Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine; and the Division of Plastic and Reconstructive Surgery, University of Illinois.

出版信息

Plast Reconstr Surg. 2018 Jan;141(1):34e-45e. doi: 10.1097/PRS.0000000000003922.

Abstract

BACKGROUND

Risk calculators are an emerging tool that provide granular, individualized risk estimation. Presently, there is a paucity of risk calculators specific to plastic surgery. Abdominoplasty is a popular plastic surgery procedure associated with moderate risks of complications, such as surgical-site infection and dehiscence, and would benefit from the ability to provide patients with accurate, personalized risk assessment.

METHODS

Abdominoplasties from the National Surgical Quality Improvement Program 2005 to 2014 database were identified by Current Procedural Terminology code. Relevant perioperative variables included age, body mass index, sex, smoking history, diabetes, American Society of Anesthesiologists class, pulmonary comorbidities, hypertension, bleeding disorders, and operative duration. Multiple logistic regressions were used to generate 30-day risk models for medical complications, surgical-site infection, wound dehiscence, and reoperation. Internal validation of model performance was conducted using C-statistics, Hosmer-Lemeshow tests, and Brier scores.

RESULTS

Among the 2499 cases identified, complication rates were as follows: medical complications, 3.8 percent; superficial surgical-site infection, 2.4 percent; deep or organ-space surgical-site infection, 1.6 percent; wound dehiscence, 1.0 percent; and reoperation, 2.0 percent. Risk prediction models were constructed and all demonstrated good predictive performance, with mean predicted risks closely matching observed complication rates. The distributions of predicted risk were wide and contained outliers with very high risk. A user-friendly, open-access online interface for these models is published at AbdominoplastyRisk.org.

CONCLUSIONS

The authors developed an internally valid risk calculator for which individual patient characteristics can be input to predict 30-day complications after abdominoplasty. Given that estimated risk can vary widely, individualized risk assessment is a way to enhance shared decision-making between surgeon and patient.

摘要

背景

风险计算器是一种新兴工具,可提供详细的个性化风险评估。目前,针对整形手术的风险计算器较少。腹壁成形术是一种常见的整形手术,存在手术部位感染和伤口裂开等中度并发症风险,若能为患者提供准确的个性化风险评估将大有裨益。

方法

通过当前手术操作术语代码从2005年至2014年国家外科质量改进计划数据库中识别腹壁成形术病例。相关围手术期变量包括年龄、体重指数、性别、吸烟史、糖尿病、美国麻醉医师协会分级、肺部合并症、高血压、出血性疾病和手术时长。使用多元逻辑回归生成医疗并发症、手术部位感染、伤口裂开和再次手术的30天风险模型。使用C统计量、Hosmer-Lemeshow检验和Brier评分对模型性能进行内部验证。

结果

在识别出的2499例病例中,并发症发生率如下:医疗并发症为3.8%;浅表手术部位感染为2.4%;深部或器官间隙手术部位感染为1.6%;伤口裂开为1.0%;再次手术为2.0%。构建了风险预测模型,所有模型均显示出良好的预测性能,平均预测风险与观察到的并发症发生率密切匹配。预测风险分布广泛,包含风险极高的异常值。这些模型的用户友好型开放获取在线界面已在AbdominoplastyRisk.org上发布。

结论

作者开发了一种内部有效的风险计算器,可输入个体患者特征以预测腹壁成形术后30天的并发症。鉴于估计风险可能差异很大,个性化风险评估是增强外科医生与患者之间共同决策的一种方式。

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