Lisowski Z M, Pirie R S, Blikslager A T, Lefebvre D, Hume D A, Hudson N P H
The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Equine Vet J. 2018 May;50(3):292-303. doi: 10.1111/evj.12801. Epub 2018 Jan 29.
Post-operative ileus (POI) is a serious condition which any horse undergoing abdominal surgery is at risk of developing, leading to increased hospitalisation time and resulting costs. Advances in the understanding of the development of equine POI are mainly based on human and rodent literature, where manipulation-induced inflammation has been identified as a trigger, with activation of resident muscularis externa macrophages playing a crucial role in the pathophysiology. Despite many pharmacological trials in all species, there is no single completely successful treatment for POI, highlighting that the condition is multifactorial in cause and requires a multimodal approach to minimise its incidence.
术后肠梗阻（POI）是一种严重的病症，任何接受腹部手术的马匹都有发生这种病症的风险，会导致住院时间延长和费用增加。对马POI发病机制的认识进展主要基于人类和啮齿动物的文献，其中已确定操作引起的炎症是一个触发因素，固有肌层巨噬细胞的激活在病理生理学中起关键作用。尽管在所有物种中都进行了许多药物试验，但对于POI并没有单一的完全成功的治疗方法，这突出表明该病症病因是多因素的，需要采取多模式方法来尽量降低其发生率。
