肉类消费与抑郁有关吗？观察性研究的荟萃分析。

Is meat consumption associated with depression? A meta-analysis of observational studies.

机构信息

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.

Hunan Key Laboratory of Joint Degeneration and Injury, Central South University, Changsha, Hunan Province, 410008, China.

出版信息

BMC Psychiatry. 2017 Dec 28;17(1):409. doi: 10.1186/s12888-017-1540-7.

DOI:10.1186/s12888-017-1540-7

PMID:29282023

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5745880/

Abstract

BACKGROUND

A number of epidemiological studies have examined the effect of meat consumption on depression. However, no conclusion has been reached. The aim of this study was to examine the relationship between meat consumption and depression.

METHODS

The electronic databases of PUBMED and EMBASE were searched up to March 2017, for observational studies that examined the relationship between meat consumption and depression. The pooled odds ratio (OR) for the prevalence of depression and the relative risk (RR) for the incidence of depression, as well as their corresponding 95% confidence interval (CI), were calculated respectively (the highest versus the lowest category of meat consumption).

RESULTS

A total of eight observational studies (three cross-sectional, three cohort and two case-control studies) were included in this meta-analysis. Specifically, six studies were related to the prevalence of depression, and the overall multi-variable adjusted OR suggested no significant association between meat consumption and the prevalence of depression (OR = 0.89, 95% CI: 0.65 to 1.22; P = 0.469). In contrast, for the three studies related to the incidence of depression, the overall multi-variable adjusted RR evidenced an association between meat consumption and a moderately higher incidence of depression (RR = 1.13, 95% CI: 1.03 to 1.24; P = 0.013).

CONCLUSIONS

Meat consumption may be associated with a moderately higher risk of depression. However, it still warrants further studies to confirm such findings due to the limited number of prospective studies.

摘要

背景

一些流行病学研究已经考察了肉类消费对抑郁症的影响。然而，尚未得出结论。本研究旨在检验肉类消费与抑郁症之间的关系。

方法

检索了 PUBMED 和 EMBASE 的电子数据库，截至 2017 年 3 月，以考察肉类消费与抑郁症之间关系的观察性研究。分别计算了抑郁患病率的合并比值比（OR）和抑郁发病率的相对风险（RR）及其相应的 95%置信区间（CI）（最高与最低肉类消费类别）。

结果

共有 8 项观察性研究（3 项横断面研究、3 项队列研究和 2 项病例对照研究）纳入了这项荟萃分析。具体而言，有 6 项研究与抑郁患病率有关，多变量调整后的整体 OR 表明，肉类消费与抑郁患病率之间无显著关联（OR=0.89，95%CI：0.65 至 1.22；P=0.469）。相比之下，与抑郁发病率相关的 3 项研究中，多变量调整后的整体 RR 表明，肉类消费与抑郁发病率中度升高之间存在关联（RR=1.13，95%CI：1.03 至 1.24；P=0.013）。