Cancer Hospital, Institute of Biomedical Sciences, Fudan University, 131 Dong'an Road, Shanghai, China.
Adv Exp Med Biol. 2017;1026:217-232. doi: 10.1007/978-981-10-6020-5_10.
Reprogramming of cellular metabolism is one of the hallmarks of breast cancer. Breast cancer cells remodel metabolic network to maintain their transformed state and survive in a harsh tumor microenvironment. Dysregulated metabolism further interacts with cellular signaling and epigenetics to promote breast cancer development. Meanwhile, breast cancer stem cells exhibit unique metabolic features, which are critical for therapeutic resistance and tumor recurrence. Besides, aberrant metabolism of breast cancer cells reshapes tumor microenvironment, such as promoting cancer vascularization and sabotaging tumor immunity, to accelerate tumor progression. These special metabolic traits not only open vulnerabilities of breast cancer by targeting essential metabolic pathways but also provide promising diagnostic and prognostic biomarkers to facilitate clinical investigations. Studies in the last few decades have significantly advanced our understanding of mechanisms underlying the reprogramming of breast cancer metabolism and metabolic regulation of breast cancer biology. Targeting tumor metabolism serves as a potentially effective therapeutic approach to suppress breast cancer.
细胞代谢重编程是乳腺癌的特征之一。乳腺癌细胞重塑代谢网络以维持其转化状态，并在恶劣的肿瘤微环境中存活。失调的代谢进一步与细胞信号和表观遗传学相互作用，促进乳腺癌的发展。同时，乳腺癌干细胞表现出独特的代谢特征，这对于治疗抵抗和肿瘤复发至关重要。此外，乳腺癌细胞异常的代谢重塑肿瘤微环境，如促进癌症血管生成和破坏肿瘤免疫，从而加速肿瘤进展。这些特殊的代谢特征不仅通过靶向关键代谢途径为乳腺癌提供了治疗弱点，还提供了有前途的诊断和预后生物标志物，以促进临床研究。过去几十年的研究显著提高了我们对乳腺癌代谢重编程和代谢调控乳腺癌生物学机制的理解。靶向肿瘤代谢是抑制乳腺癌的一种潜在有效治疗方法。
