基于人群的纵向出生后生活研究中粪便样本中钙卫蛋白的正常参考值。

Normal values for calprotectin in stool samples of infants from the population-based longitudinal born into life study.

机构信息

a Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory , Uppsala University , Uppsala , Sweden.

b Department of Forest Mycology and Plant Pathology, Science for Life Laboratories , Swedish University of Agricultural Sciences , Uppsala , Sweden.

出版信息

Scand J Clin Lab Invest. 2018 Feb-Apr;78(1-2):120-124. doi: 10.1080/00365513.2017.1420216. Epub 2017 Dec 28.

DOI:10.1080/00365513.2017.1420216

PMID:29283308

Abstract

Faecal calprotectin is a protein used as a diagnostic marker for inflammatory bowel diseases. We determined upper limits for normal calprotectin values for neonatal, 6, 12 and 24 months old children using a turbidimetric immunoassay in a cohort of Swedish children. The advantage of the method is that opposite to previously used enzyme-linked immunosorbent assay (ELISA) method, it enables measuring single samples, and thus, shortens the analysis time significantly. There were 72 samples (41.7% female) collected neonatally, 63 samples (34.9% female) at 6 months, 60 samples (40.0% female) at 12 months and 51 samples (43.1% female) at 24 months. The upper limits for normal values were 233, 615, 136 and 57 µg mg for infants aged 0, 6, 12 and 24 months, respectively.

摘要

粪便钙卫蛋白是一种用于诊断炎症性肠病的蛋白质标志物。我们使用比浊免疫分析法在瑞典儿童队列中确定了新生儿、6 个月、12 个月和 24 个月大的儿童正常钙卫蛋白值的上限。该方法的优点是与之前使用的酶联免疫吸附测定（ELISA）方法不同，它能够测量单个样本，从而显著缩短分析时间。共收集了 72 份（41.7%为女性）新生儿样本、63 份（34.9%为女性）6 个月样本、60 份（40.0%为女性）12 个月样本和 51 份（43.1%为女性）24 个月样本。0、6、12 和 24 个月婴儿的正常钙卫蛋白值上限分别为 233、615、136 和 57µg/mg。