Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Juárez 32310, Chihuahua, Mexico.
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, Morelos, Mexico.
Molecules. 2017 Dec 28;23(1):67. doi: 10.3390/molecules23010067.
Extensive knowledge of diabetes and its complications is helpful to find new drugs for proper treatment to stop degenerative changes derived from this disease. In this context, chrysin (5,7-dihydroxyflavone) is a natural product that occurs in a variety of flowers and fruits with anti-inflammatory and antidiabetic effects, among others. Thus, a diabetic model in athymic nude mice was developed and used to establish the ability of chrysin to decrease the secretion of pro-inflammatory cytokines. Also, it was determined the acute (50 mg/kg) and sub-acute (50 mg/kg/day/10 days) antidiabetic and antihyperlipidemic activities after the period of time treatment. Results indicate that chrysin has significant acute antihyperglycemic and antidiabetic effects in nude diabetic mice ( < 0.05). Moreover, triglyceride blood levels were reduced and IL-1β and TNF-α were diminished after 10 days' treatment compared with control group ( < 0.05). In conclusion, it was found that chrysin could produce similar effects as metformin, a drug used for the treatment of diabetes, since both test samples decreased glucose and triglycerides levels, they impaired the generation of pro-inflammatory cytokines involved in the development of diabetes and its consequences, such as atherosclerosis and other cardiovascular diseases.
深入了解糖尿病及其并发症有助于寻找新的药物，进行适当的治疗，以阻止这种疾病引起的退行性变化。在这种情况下，白杨素（5,7-二羟基黄酮）是一种天然产物，存在于各种花卉和水果中，具有抗炎和抗糖尿病作用等。因此，在无胸腺裸鼠中建立了糖尿病模型，并用于确定白杨素降低促炎细胞因子分泌的能力。此外，还确定了急性（50mg/kg）和亚急性（50mg/kg/天/10 天）治疗后一段时间的抗糖尿病和抗高血脂活性。结果表明，白杨素对裸鼠糖尿病具有显著的急性降血糖和抗糖尿病作用（<0.05）。此外，与对照组相比，经过 10 天的治疗后，甘油三酯水平降低，IL-1β和 TNF-α减少（<0.05）。总之，研究发现白杨素可以产生类似于二甲双胍的作用，二甲双胍是一种用于治疗糖尿病的药物，因为这两种试验样品都降低了葡萄糖和甘油三酯水平，它们损害了参与糖尿病及其后果（如动脉粥样硬化和其他心血管疾病）发展的促炎细胞因子的产生。
