Pecorini Gianni, Ferraro Elisabetta, Puppi Dario
BIOLab Research Group, Department of Chemistry and Industrial Chemistry, University of Pisa, UdR INSTM Pisa, Via Moruzzi 13, 56124 Pisa, Italy.
Department of Biology, University of Pisa, S.S. 12 Abetone e Brennero 4, 56127 Pisa, Italy.
Pharmaceutics. 2023 Feb 13;15(2):628. doi: 10.3390/pharmaceutics15020628.
Flavonoids are natural compounds that are attracting great interest in the biomedical field thanks to the wide spectrum of their biological properties. Their employment as anticancer, anti-inflammatory, and antidiabetic drugs, as well as for many other pharmacological applications, is extensively investigated. One of the most successful ways to increase their therapeutic efficacy is to encapsulate them into a polymeric matrix in order to control their concentration in the physiological fluids for a prolonged time. The aim of this article is to provide an updated overview of scientific literature on the polymeric systems developed so far for the controlled release of flavonoids. The different classes of flavonoids are described together with the polymers most commonly employed for drug delivery applications. Representative drug delivery systems are discussed, highlighting the most common techniques for their preparation. The flavonoids investigated for polymer system encapsulation are then presented with their main source of extraction and biological properties. Relevant literature on their employment in this context is reviewed in relationship to the targeted pharmacological and biomedical applications.
黄酮类化合物是天然化合物，由于其广泛的生物学特性，在生物医学领域引起了极大的关注。它们作为抗癌、抗炎和抗糖尿病药物以及许多其他药理应用的研究正在广泛开展。提高其治疗效果最成功的方法之一是将它们封装在聚合物基质中，以便在生理流体中长时间控制其浓度。本文的目的是提供关于迄今为止开发的用于黄酮类化合物控释的聚合物系统的科学文献的最新综述。描述了不同类别的黄酮类化合物以及药物递送应用中最常用的聚合物。讨论了代表性的药物递送系统，突出了其制备的最常见技术。然后介绍了研究用于聚合物系统封装的黄酮类化合物及其主要提取来源和生物学特性。就其在这种情况下的应用，结合靶向药理和生物医学应用对相关文献进行了综述。
