Fu Jian-Guang, Shi Chao, Xu Cheng, Lin Qin, Zhang Jun, Yi Qian-Hua, Zhang Jun, Bao Chang-Jun, Huo Xiang, Zhu Ye-Fei, Ai Jing, Xing Zheng
Medical School and Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, China.
Key Lab of Enteric Pathogenic Microbiology, Ministry of Health, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
PLoS One. 2017 Dec 28;12(12):e0186090. doi: 10.1371/journal.pone.0186090. eCollection 2017.
A total of 64 acute gastroenteritis outbreaks with 2,953 patients starting in December of 2016 and occurring mostly in the late spring of 2017 were reported in Jiangsu, China. A recombinant GII.P16-GII.2 norovirus variant was associated with 47 outbreaks (73.4%) for the gastroenteritis epidemic, predominantly occurring in February and March of 2017. Sequence analysis of the RNA-dependent RNA polymerase (RdRp) and capsid protein of the viral isolates from these outbreaks confirmed that this GII.P16-GII.2 strain was the GII.P16-GII.2 variant with the intergenotypic recombination, identified in Taiwan, Hong Kong, and other cities in China in 2016. This GII.P16-GII.2 recombinant variant appeared to a re-emerging strain, firstly identified in 2011-2012 from Japan and USA but might be independently originated from other GII.P16-GII.2 variants for sporadic and outbreaks of gastroenteritis in Japan and China before 2016. Further identification of unique amino acid mutations in both VP1 and RdRp of NoV strain as shown in this report may provide insight in explaining its structural and antigenic changes, potentially critical for the variant recombinant to gain its predominance in causing regional and worldwide epidemics.
2016年12月至2017年春末期间，中国江苏省共报告了64起急性肠胃炎疫情，涉及2953名患者。一种重组GII.P16-GII.2诺如病毒变体与47起（73.4%）肠胃炎疫情有关，主要发生在2017年2月和3月。对这些疫情中病毒分离株的RNA依赖RNA聚合酶（RdRp）和衣壳蛋白进行序列分析，证实该GII.P16-GII.2毒株是2016年在台湾、香港及中国其他城市发现的具有基因间重组的GII.P16-GII.2变体。这种GII.P16-GII.2重组变体似乎是一种重新出现的毒株，最早于2011 - 2012年在日本和美国被发现，但可能独立起源于2016年前在日本和中国导致散发性和爆发性肠胃炎的其他GII.P16-GII.2变体。本报告中所示的诺如病毒株VP1和RdRp中独特氨基酸突变的进一步鉴定，可能有助于解释其结构和抗原变化，这可能是该变体重组株在导致地区和全球疫情中占据主导地位的关键因素。
