来自核桃楸新鲜果皮的二芳基庚烷类化合物。
Diarylheptanoids from the fresh pericarps of Juglans sigillata.
作者信息
Liang Jingjing, Peng Xiaogang, Zhou Jia, Zhou Ming, Ruan Hanli
机构信息
a Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy , Tongji Medical College of Huazhong University of Science and Technology , Wuhan , People's Republic of China.
出版信息
Nat Prod Res. 2018 Oct;32(20):2457-2463. doi: 10.1080/14786419.2017.1419235. Epub 2017 Dec 28.
One new diarylheptanoid (3S)-3', 4″-epoxy-1-(4'-hydroxylphenyl)-7-(3″-hydroxylphenyl) heptane-3-hydroxy (1), together with eleven known ones (2-12), was isolated from the fresh pericarps of Juglans sigillata. Their structures were elucidated on the basis of extensive spectroscopic methods, including HR-ESI-MS, 1D and 2D-NMR. All isolates were evaluated for their cytotoxic activities in vitro against the growth of human cancer cells lines HT-29 and MCF-7 by MTT assay.
从核桃楸新鲜果皮中分离得到一个新的二芳基庚烷类化合物(3S)-3', 4″-环氧-1-(4'-羟基苯基)-7-(3″-羟基苯基)庚烷-3-醇(1)，以及11个已知化合物(2 - 12)。通过包括高分辨电喷雾电离质谱、一维和二维核磁共振在内的多种光谱方法对其结构进行了鉴定。采用MTT法对所有分离物进行体外细胞毒性活性评价，检测其对人癌细胞系HT - 29和MCF - 7生长的影响。
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