从 的新鲜果皮中分离得到的酚类成分。
Phenolic constituents from the fresh pericarps of .
机构信息
School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan, People's Republic of China.
出版信息
Nat Prod Res. 2021 Apr;35(8):1242-1248. doi: 10.1080/14786419.2019.1644631. Epub 2019 Jul 22.
Three new phenolic compounds, 2,3,4-trihydroxy-1-(4'-hydroxybenzyl)benzoic acid (), 2,3,4-trihydroxy-1-(4'-hydroxy-3'-methoxybenzyl)benzoic acid (), and 2-(4'-hydroxy-3'-methoxybenzyl)-3,5-dimethoxy-1,4-benzoquinone (), were isolated from the fresh pericarps of Dode. Their structures were elucidated by integrated spectroscopic techniques. Bioactivity screening results showed that compounds exhibited moderate neuroprotective effects against HO-induced or CoCl-induced cellular damage in human neuroblastoma SH-SY5Y cell line.
从新鲜的桃金娘果皮中分离得到三种新的酚类化合物
2,3,4-三羟基-1-(4'-羟基苄基)苯甲酸（）、2,3,4-三羟基-1-(4'-羟基-3'-甲氧基苄基)苯甲酸（）和 2-(4'-羟基-3'-甲氧基苄基)-3,5-二甲氧基-1,4-苯醌（）。通过综合光谱技术阐明了它们的结构。生物活性筛选结果表明，化合物对 HO 诱导或 CoCl 诱导的人神经母细胞瘤 SH-SY5Y 细胞系的细胞损伤具有中等的神经保护作用。
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