河北核桃果皮中的二芳基庚烷类化合物。
Diarylheptanoids from the fresh pericarps of Juglans hopeiensis.
机构信息
School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Hangkonglu 13, Wuhan 430030, People's Republic of China.
School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Hangkonglu 13, Wuhan 430030, People's Republic of China.
出版信息
Fitoterapia. 2019 Jul;136:104165. doi: 10.1016/j.fitote.2019.05.004. Epub 2019 May 7.
Ten new diarylheptanoids (1-10), including five diarylether-type (1-5), three biaryl-type (6-8), and two linear type (9-10), along with eighteen known ones, were isolated from the fresh pericarps of Juglans hopeiensis Hu. Their structures were settled by integrated spectroscopic techniques, and their absolute configurations were determined by a combination of circular dichroism analysis, optical rotations, and NOESY experiments. Screening results showed that some isolated diarylheptanoids exhibited moderate neuroprotective effects on HO-induced or CoCl-induced cellular damage in human neuroblastoma SH-SY5Y cells.
从河北核桃的新鲜果皮中分离得到 10 个新的二芳基庚烷类化合物（1-10），包括 5 个二芳基醚型（1-5）、3 个联苯型（6-8）和 2 个直链型（9-10），以及 18 个已知化合物。它们的结构通过综合光谱技术确定，绝对构型通过圆二色分析、旋光度和 NOESY 实验的结合来确定。筛选结果表明，一些分离得到的二芳基庚烷类化合物对 HO 诱导或 CoCl 诱导的人神经母细胞瘤 SH-SY5Y 细胞损伤具有中等的神经保护作用。
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