Prabhu Allama, Prasanna B G, Sakeenabhi B, Prashanth G M, Subramaniam R, Ragher Mallikarjuna
Department of Public Health Dentistry, College of Dental Sciences, Davanagere, Karnataka, India.
Department of Prosthodontics, College of Dental Sciences, Davanagere, Karnataka, India.
J Pharm Bioallied Sci. 2017 Nov;9(Suppl 1):S112-S116. doi: 10.4103/jpbs.JPBS_121_17.
Dental caries remains the most important dental health problem in developing countries. Application of varnish on tooth surfaces is shown to promote the uptake of firmly bound fluoride by enamel, which is considered important. Along with the incorporation of fluoride into the crystalline lattice, there is formation of calcium fluoride compounds on enamel.
Seventy deciduous canines were covered with nail polish. A window measuring 4 mm × 4 mm was left on their buccal surface, These were randomly assigned to seven groups ( = 6): S: sound enamel not subjected to any regimen or treatment; N: negative control, subjected to the pH-cycling regimen without any treatment; D1 and D2: subjected to the pH-cycling regimen and treated two times daily with 1100 and 500 ppm dentifrice, respectively; VF: fluoride varnish (subjected to F-varnish before and in the middle of the pH-cycling regimen); and VF + D1 and VF + D2. After a period of 10 days, sectioning of teeth was done, and enamel demineralization was measured.
The combination of dentifrice and varnish (groups VF + D1 and VF + D2) significantly reduced demineralization compared with the N group at all distances evaluated ( < 0.05), but the combination did not differ from the dentifrice groups at most distances from the surface ( > 0.05).
The results of this study suggest that the combination of F-varnish with dentifrices containing 500 or 1100 ppm F is not more effective in reducing demineralization in primary teeth than the isolated effect of dentifrice containing 1100 ppm.
龋齿仍然是发展中国家最重要的口腔健康问题。在牙齿表面涂抹清漆可促进牙釉质对紧密结合的氟的吸收,这一点很重要。随着氟融入晶格,牙釉质上会形成氟化钙化合物。
七十颗乳牙用指甲油覆盖。在其颊面留一个4毫米×4毫米的窗口。这些牙齿被随机分为七组(每组 = 6):S组:健康牙釉质,未接受任何方案或治疗;N组:阴性对照组,接受pH循环方案但未进行任何治疗;D1组和D2组:接受pH循环方案,分别每天用1100 ppm和500 ppm的牙膏治疗两次;VF组:氟漆组(在pH循环方案之前和中间使用氟漆);以及VF + D1组和VF + D2组。10天后,对牙齿进行切片,并测量牙釉质脱矿情况。
与N组相比,牙膏和氟漆联合使用组(VF + D1组和VF + D2组)在所有评估距离处均显著降低了脱矿程度(P < 0.05),但在距表面的大多数距离处,联合使用组与牙膏组没有差异(P > 0.05)。
本研究结果表明,含500 ppm或1100 ppm氟的牙膏与氟漆联合使用在减少乳牙脱矿方面并不比含1100 ppm氟的牙膏单独使用更有效。