Sh Priyadarshini, Raghu Ramya, Shetty Ashish, Gautham Pm, Reddy Satyanarayana, Srinivasan Raghu
Department of Conservative Dentistry and Endodontics, Bangalore Institute of Dental Sciences and Postgraduate Research Center, Bangalore, India.
J Conserv Dent. 2013 May;16(3):203-7. doi: 10.4103/0972-0707.111314.
Dental caries is one of the most prevalent infectious diseases affecting the human dentition. Fluorides are effective anti-carious agents and have been widely used for caries prevention in the form of systemic and topical fluorides. Neutral sodium fluoride (NaF) is commonly used as a topical fluoride agent. A special category of topical fluorides are organic fluorides in the form of amine fluorides (AmF). Researchers have reported that AmF is superior to inorganic fluorides in improving the caries resistance of enamel due to the significant anti-enzyme effect of the organic fragment.
The aim of the present study was to compare the enamel surface micro hardness after topical application of NaF and AmF solutions.
Twenty fresh samples of sound human enamel were treated with demineralizing solution for 72 h and divided into Group A (treated with NaF) and Group B (treated with AmF) solutions for 3 min twice daily for 7 days. In between treatment, the samples were stored in artificial saliva. The enamel surface hardness was measured with Vickers hardness test at baseline, post-demineralization and post-treatment with two different fluoride solutions (NaF and AmF) and a comparative analysis was made.
The increase in mean micro hardness of human enamel after treatment with AmF application was found to be statistically significant (P < 0.01) when compared to the mean micro hardness after treatment with NaF.
Fluoride enhances the remineralization process by accelerating the growth of enamel crystals that have been demineralized. It can be concluded from the present study that AmF compounds result in a marked increase in enamel micro hardness when compared to NaF.
龋齿是影响人类牙列的最常见传染病之一。氟化物是有效的防龋剂，已以全身用氟化物和局部用氟化物的形式广泛用于预防龋齿。中性氟化钠（NaF）通常用作局部用氟化物制剂。一类特殊的局部用氟化物是胺氟化物（AmF）形式的有机氟化物。研究人员报告称，由于有机片段具有显著的抗酶作用，AmF在提高牙釉质抗龋性方面优于无机氟化物。
本研究的目的是比较局部应用NaF和AmF溶液后牙釉质表面显微硬度。
将20个新鲜的健康人牙釉质样本用脱矿溶液处理72小时，然后分为A组（用NaF处理）和B组（用AmF处理），每天两次，每次3分钟，持续7天。在处理期间，样本保存在人工唾液中。在基线、脱矿后以及用两种不同氟化物溶液（NaF和AmF）处理后，用维氏硬度测试测量牙釉质表面硬度，并进行比较分析。
与用NaF处理后的平均显微硬度相比，用AmF处理后人牙釉质的平均显微硬度增加具有统计学意义（P < 0.01）。
氟化物通过加速已脱矿的牙釉质晶体的生长来增强再矿化过程。从本研究可以得出结论，与NaF相比，AmF化合物可使牙釉质显微硬度显著增加。
