Xiong Fang, Hu Lingqing, Zhang Yun, Xiao Xiao
Center of Reproduction Medicine, Maternal and Child Health Hospital of Wuxi, Wuxi, Jiangsu 214002, P.R. China.
Exp Ther Med. 2017 Dec;14(6):5405-5410. doi: 10.3892/etm.2017.5204. Epub 2017 Sep 27.
We investigated the correlation of hypertensive disorders in pregnancy with different procedures of fertilization, and analyzed pregnancy outcomes of patients with hypertensive disorders in pregnancy. A retrospective analysis was performed on the medical records of 658 maternity patients who conceived through fertilization in Maternal and Child Health Hospital of Wuxi. Patients were divided into two groups according to different fertilization procedures: i) the routine fertilization-embryo transfer group (IVF-ET group, 377 cases) and ii) intra-cytoplasmic sperm injection-embryo transfer group (ICSI-ET group, 281 cases). Consequently, patients were further divided into two groups according to different embryo transfer cycles: the fresh embryo transfer group (F-ET group, 446 cases) and the frozen-thawed embryo transfer group (T-ET group, 212 cases). Characteristics of patients in each group were evaluated, and incidence of hypertensive disorders in pregnancy resulting from different assisted reproductive technology was compared. Among patients who conceived through IVF, there were 56 cases of hypertensive disorders in pregnancy, including 21 cases of gestational hypertension, 34 cases of pre-eclampsia and 1 case of eclampsia. The odds ratio (OR) of gestational hypertension in the comparison between the ICSI-ET and IVF-ET groups was 2.01 (0.81-4.74), and was reduced to 1.69 (0.70-4.02) after correction. The difference of OR in twin-birth patients of the two groups was statistically significant, but the difference in single-birth patients was not statistically significant. The odds ratio (OR) of gestational hypertension in the comparison between the F-ET and T-ET groups was 0.44 (0.13-1.34), and became 0.49 (0.15-1.51) after correction. The odds ratio of pre-eclampsia in the comparison between the ICSI-ET and IVF-ET groups was 1.36 (0.42-4.18), and was reduced to 1.17 (0.36-3.62) after correction. The odds ratio of pre-eclampsia in the comparison between the F-ET and T-ET groups was 0.93 (0.42-1.96), and became 0.98 (0.44-2.12) after correction. The differences were not statistically significant. The risk of onset of hypertensive disorders in pregnancy has a certain correlation with the ICSI fertilization technology, but has no apparent correlation with embryo transfer cycles.
我们研究了妊娠高血压疾病与不同受精程序之间的相关性，并分析了妊娠高血压疾病患者的妊娠结局。对无锡市妇幼保健院658例通过受精受孕的产妇病历进行回顾性分析。根据不同的受精程序将患者分为两组：i）常规体外受精-胚胎移植组（IVF-ET组，377例）和ii）卵胞浆内单精子注射-胚胎移植组（ICSI-ET组，281例）。随后，根据不同的胚胎移植周期将患者进一步分为两组：新鲜胚胎移植组（F-ET组，446例）和冻融胚胎移植组（T-ET组，212例）。评估每组患者的特征，并比较不同辅助生殖技术导致的妊娠高血压疾病的发生率。在通过IVF受孕的患者中，有56例妊娠高血压疾病，包括21例妊娠期高血压、34例先兆子痫和1例子痫。ICSI-ET组与IVF-ET组相比，妊娠期高血压的优势比（OR）为2.01（0.81-4.74），校正后降至1.69（0.70-4.02）。两组双胎患者的OR差异有统计学意义，但单胎患者的差异无统计学意义。F-ET组与T-ET组相比，妊娠期高血压的优势比（OR）为0.44（0.13-1.34），校正后变为0.49（0.15-1.51）。ICSI-ET组与IVF-ET组相比，先兆子痫的优势比为1.36（0.42-4.18），校正后降至1.17（0.36-3.62）。F-ET组与T-ET组相比，先兆子痫的优势比为0.93（0.42-1.96），校正后变为0.98（0.44-2.12）。差异无统计学意义。妊娠高血压疾病的发病风险与ICSI受精技术有一定相关性，但与胚胎移植周期无明显相关性。
