Juno Fertility, Toronto, ON, Canada.
OBGYN Department, McMaster University, Hamilton, ON, Canada.
J Assist Reprod Genet. 2021 Mar;38(3):651-659. doi: 10.1007/s10815-021-02061-z. Epub 2021 Jan 19.
Recent publications suggested that the risk for pre-eclampsia (PE) is higher with frozen-thawed embryo transfers (FETs) compared to fresh transfers (IVF-ETs). These studies were based on old data that reflects outdated practices. In this paper, we wanted to assess the incidence of PE in current assisted reproductive technology (ART) practice.
In this cohort study, we present the incidence of PE in all births in the province of Ontario, Canada, for the years 2013-2017 for FET, IVF-ET, and natural conceptions (NC). We also compare our findings to previous studies in a meta-analysis that includes over 4 million births.
The results of our study show that contemporary practice of ART results in comparable risk for PE between FET and IVF-ET; however, the risk is higher than NC.
Current ART practice is associated with a lower risk for PE in frozen embryo transfer; this RR can be further attenuated by using ovulatory endometrial preparation for FETs.
最近的出版物表明，与新鲜胚胎移植（IVF-ET）相比，冷冻-解冻胚胎移植（FET）发生子痫前期（PE）的风险更高。这些研究基于反映过时实践的旧数据。在本文中，我们希望评估当前辅助生殖技术（ART）实践中 PE 的发生率。
在这项队列研究中，我们报告了 2013 年至 2017 年加拿大安大略省所有活产的 FET、IVF-ET 和自然受孕（NC）的 PE 发生率。我们还通过包括超过 400 万例活产的荟萃分析将我们的研究结果与之前的研究进行了比较。
我们的研究结果表明，当代 ART 实践在 FET 和 IVF-ET 之间产生了可比的 PE 风险；然而，这种风险高于 NC。
目前的 ART 实践与冷冻胚胎移植中 PE 的风险较低相关；通过使用 FET 的排卵子宫内膜准备，可以进一步降低这种 RR。
