Luo Dong, Hou Qun, Yu Jianzhong, Yu Dan
Department of Neurology, School of Medicine, The Second Affiliated Hospital of Zhejiang University, Hangzhou 310009, Zhejiang, China.
Department of Neurology, Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou 310006, Zhejiang, China.
Oncotarget. 2017 Nov 18;8(62):105915-105922. doi: 10.18632/oncotarget.22509. eCollection 2017 Dec 1.
Some previous studies suggested telomere length was associated with the risk of ischemic stroke (IS). The aim of this study was to further confirm the association between relative telomere length (RTL) and risk of IS and to especially explore its correlation with the risk of high-risk stroke population in southern Chinese Han. RTL was determined by using real-time quantitative polymerase chain reaction from 400 ischemic stroke patients, 409 high-risk stroke populations and 399 healthy controls. The correlations between the controls and the risk of high-risk and ischemic stroke were evaluated by using an unconditional logistic regression. IS patients have shown longer RTL than controls (median1.52vs1.11, p60 years) and gender suggested that the first and second tertile of RTL were correlated with the risk of IS in each group when the second tertile was used as a reference. However, the increased risk for high-risk stroke populations were only presented in the first tertile of RTL in the age≤60 years and female groups. the RTL was associated with an increased risk of ischemic stroke, while it elevated the risk of high-risk stroke in some specific subpopulations.
一些先前的研究表明，端粒长度与缺血性中风（IS）的风险相关。本研究的目的是进一步证实相对端粒长度（RTL）与IS风险之间的关联，并特别探讨其与中国南方汉族高危中风人群风险的相关性。采用实时定量聚合酶链反应测定了400例缺血性中风患者、409例高危中风人群和399例健康对照者的RTL。通过无条件逻辑回归评估对照组与高危和缺血性中风风险之间的相关性。IS患者的RTL比对照组更长（中位数1.52对1.11，p<0.001）。年龄分层（≤60岁和>60岁）和性别分析表明，当以第二个三分位数为参照时，RTL的第一个和第二个三分位数与每组中IS的风险相关。然而，高危中风人群风险的增加仅出现在年龄≤60岁组和女性组的RTL第一个三分位数中。RTL与缺血性中风风险增加相关，而在某些特定亚组中它增加了高危中风的风险。
