Sun Heng, Zou Jing, Chen Ling, Zu Xuyu, Wen Gebo, Zhong Jing
Institute of Clinical Medicine, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China.
Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China.
Mol Clin Oncol. 2017 Dec;7(6):935-942. doi: 10.3892/mco.2017.1429. Epub 2017 Sep 29.
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks expression of the estrogen and progesterone receptor and does not overexpress human epidermal growth factor 2 receptor protein. TNBC is associated with special characteristics, including aggressiveness, poor prognosis and poor response to treatment, and has been attracting increasing attention worldwide. Obesity is a well-documented factor exerting a significant effect on the development of breast cancer, including TNBC. The purpose of the present review was to focus on the association between obesity and TNBC and provide a summary of novel research findings. The aim was to highlight the association between TNBC and obesity and provide an overview of novel outlooks on clinical issues, biological rationale, novel targeted therapies and prognosis, in order to draw attention to the significance of weight management, primary prevention, early diagnosis and treatment of this intractable disease.
三阴性乳腺癌（TNBC）是乳腺癌的一种亚型，其缺乏雌激素和孕激素受体的表达，且不高表达人表皮生长因子2受体蛋白。TNBC具有一些特殊特征，包括侵袭性、预后不良以及对治疗反应不佳，在全球范围内受到越来越多的关注。肥胖是一个有充分文献记载的对包括TNBC在内的乳腺癌发展有显著影响的因素。本综述的目的是聚焦肥胖与TNBC之间的关联，并总结新的研究发现。目的是强调TNBC与肥胖之间的关联，并概述关于临床问题、生物学原理、新型靶向治疗和预后的新观点，以便引起人们对这种难治性疾病体重管理、一级预防、早期诊断和治疗重要性的关注。
