Lee Chae Min, Fang Sungsoon
Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Korea.
Department of Biomedical Sciences, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
J Obes Metab Syndr. 2023 Dec 30;32(4):312-321. doi: 10.7570/jomes23044. Epub 2023 Nov 28.
Obesity, now officially recognized as a disease requiring intervention, has emerged as a significant health concern due to its strong association with elevated susceptibility to diverse diseases and various types of cancer, including breast cancer. The link between obesity and cancer is intricate, with obesity exerting a significant impact on cancer recurrence and elevated mortality rates. Among the various subtypes of breast cancer, triple-negative breast cancer (TNBC) is the most aggressive, accounting for 15% to 20% of all cases. TNBC is characterized by low expression of estrogen receptors and progesterone receptors as well as the human epidermal growth factor 2 receptor protein. This subtype poses distinct challenges in terms of treatment response and exhibits strong invasiveness. Furthermore, TNBC has garnered attention because of its association with obesity, in which excess body fat and reduced physical activity have been identified as contributing factors to the increased incidence of this aggressive form of breast cancer. In this comprehensive review, the impact of obesity on TNBC was explored. Specifically, we focused on the three key mechanisms by which obesity affects TNBC development and progression: modification of the immune profile, facilitation of fibrosis, and initiation of senescence. By comprehensively examining these mechanisms, we illuminated the complex interplay between TNBC and obesity, facilitating the development of novel approaches for prevention, early detection, and effective management of this challenging disease.
肥胖现已被正式认定为一种需要干预的疾病，由于它与多种疾病及各类癌症（包括乳腺癌）的易感性升高密切相关，已成为一个重大的健康问题。肥胖与癌症之间的联系错综复杂，肥胖对癌症复发和死亡率升高有着重大影响。在乳腺癌的各种亚型中，三阴性乳腺癌（TNBC）最为侵袭性强，占所有病例的15%至20%。TNBC的特征是雌激素受体、孕激素受体以及人表皮生长因子2受体蛋白的低表达。这种亚型在治疗反应方面带来了独特的挑战，并且具有很强的侵袭性。此外，TNBC因其与肥胖的关联而受到关注，其中过多的体脂和体力活动减少已被确定为这种侵袭性乳腺癌发病率增加的促成因素。在这篇全面综述中，探讨了肥胖对TNBC的影响。具体而言，我们重点关注肥胖影响TNBC发展和进展的三个关键机制：免疫谱的改变、纤维化的促进以及衰老的引发。通过全面研究这些机制，我们阐明了TNBC与肥胖之间复杂的相互作用，有助于开发针对这种具有挑战性疾病的预防、早期检测和有效管理的新方法。
