Zhang Li, Zhou Pingping, Meng Zhaowei, Gong Lu, Pang Chongjie, Li Xue, Jia Qiang, Tan Jian, Liu Na, Hu Tianpeng, Zhang Qing, Jia Qiyu, Song Kun
Department of Infectious Diseases, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Mol Clin Oncol. 2017 Dec;7(6):1039-1044. doi: 10.3892/mco.2017.1433. Epub 2017 Oct 2.
Infectious mononucleosis (IM) due to Epstein-Barr virus infection is common. Uric acid (UA) is an important endogenous antioxidant. To the best of our knowledge, the association between UA and IM has not been comprehensively investigated to date. The aim of the present study was to investigate this association in Chinese patients. A total of 95 patients (47 men and 48 women) with IM were recruited, along with 95 healthy controls. Clinical data were classified by patient sex. Receiver operating characteristic (ROC) curve analysis was adopted to determine the cut-off values of UA for IM diagnosis and prediction. Crude and adjusted odds ratios (ORs) of UA for IM were analyzed by binary logistic regression. The UA levels were significantly lower in IM patients compared with those in controls. In addition, UA levels in men were significantly higher compared with those in women. The ROC curve demonstrated good diagnostic and predictive values of UA for IM in both sexes. The UA cut-off values were 326.00 and 243.50 µmol/l for diagnosing IM in men and women, respectively, with a diagnostic accuracy of 76.596 and 80.208%, respectively. Binary logistic regression analysis revealed a significant risk of IM in the low UA quartiles in both sexes. Following adjustments, the ORs even increased. Women with low UA levels appeared to be more susceptible to IM. For example, the crude ORs in quartile 1 were 24.000 and 52.500 for men and women, respectively, and the respective adjusted ORs were 31.437 and 301.746 (all P<0.01). To the best of our knowledge, the present study is the first to demonstrate the inverse association between UA and IM, suggesting a progressive decrease of antioxidant reserve in IM. Moreover, low UA was suggestive of IM, particularly in women.
由爱泼斯坦 - 巴尔病毒感染引起的传染性单核细胞增多症（IM）很常见。尿酸（UA）是一种重要的内源性抗氧化剂。据我们所知，迄今为止尚未对UA与IM之间的关联进行全面研究。本研究的目的是在中国患者中调查这种关联。共招募了95例IM患者（47例男性和48例女性）以及95名健康对照者。临床数据按患者性别分类。采用受试者工作特征（ROC）曲线分析来确定用于IM诊断和预测的UA临界值。通过二元逻辑回归分析UA对IM的粗比值比（OR）和调整后的OR。与对照组相比，IM患者的UA水平显著降低。此外，男性的UA水平显著高于女性。ROC曲线显示UA对男女IM均具有良好的诊断和预测价值。诊断男性和女性IM的UA临界值分别为326.00和243.50 μmol/l，诊断准确率分别为76.596%和80.208%。二元逻辑回归分析显示，男女UA低四分位数组患IM的风险均显著增加。调整后，OR甚至更高。UA水平低的女性似乎更容易患IM。例如，第1四分位数组中男性和女性的粗OR分别为24.000和52.500，各自调整后的OR分别为31.437和301.746（均P<0.01）。据我们所知，本研究首次证明了UA与IM之间的负相关，表明IM患者抗氧化储备逐渐减少。此外，低UA提示患有IM，尤其是在女性中。
