a Department of Biotechnology , National Institute of Technology Raipur , Raipur , India.
J Drug Target. 2018 Nov;26(9):766-776. doi: 10.1080/1061186X.2017.1419478. Epub 2018 Jan 8.
The myriad of complications associated with diabetes is closely linked with the generation of reactive species or free radicals leading to oxidative and nitrosative stress. Increased oxidative stress is an important cause and result of diabetes and it is thought to underlie the cellular changes that lead to diabetic complications. The whole cause and effect form a vicious circle, underlying many layers of potential therapeutics in its research. In this regards, this review outlines the briefs about the correlation of type 2 diabetes and oxidative (or nitrosative) stress and also compiles the potentiality of various antioxidants that are being or can be used for alleviating the oxidative stress. Since the complications are like a knit matrix of numerous deteriorating mechanisms, a single antioxidant therapeutic approach cannot be an answer. Therefore, it is important to develop new fixed-dose combinations of effective antioxidants that target key reactive oxygen (or nitrogen)-producing sources, mimic endogenous antioxidants and scavenge the reactive species generated balancing the pro and antioxidant cycle. This review focuses on the preclinical and clinical trial data with therapeutic antioxidants in type 2 diabetes along with a brief focus on success and failures of antioxidant-based therapy.
与糖尿病相关的众多并发症与活性物质或自由基的产生密切相关，导致氧化和硝化应激。氧化应激增加是糖尿病的一个重要原因和结果，它被认为是导致糖尿病并发症的细胞变化的基础。整个因果关系形成了一个恶性循环，在其研究中存在着许多潜在的治疗方法。在这方面，本综述概述了 2 型糖尿病与氧化（或硝化）应激的相关性，并汇编了各种正在或可能用于缓解氧化应激的抗氧化剂的潜力。由于并发症就像一个由无数恶化机制组成的编织矩阵，单一的抗氧化治疗方法不可能是答案。因此，开发针对关键活性氧（或氮）产生源的有效抗氧化剂的新型固定剂量组合，模拟内源性抗氧化剂并清除产生的活性物质，以平衡促氧化剂和抗氧化剂循环，这一点非常重要。本综述重点介绍了 2 型糖尿病中具有治疗作用的抗氧化剂的临床前和临床试验数据，并简要介绍了基于抗氧化剂的治疗的成功和失败。
