miR-152 通过抑制 ERBB3 参与卵巢癌的增殖和转移。

Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, P.R. China.

Department of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

Int J Mol Med. 2018 Mar;41(3):1529-1535. doi: 10.3892/ijmm.2017.3324. Epub 2017 Dec 15.

MicroRNAs (miRNAs) participate in post-transcriptional regulation by targeting the 3' untranslated region of target genes that are involved in diverse biological processes. To the best of our knowledge, the association between miR‑152 and ERBB3 in ovarian cancer remains unclear. In the present study, a negative correlation between miR‑152 and ERBB3 in ovarian cancer was observed. The luciferase reporter gene assay results demonstrated that miR‑152 negatively regulated ERBB3 in SKOV3 and OVCAR3 ovarian cancer cells. Furthermore, our results revealed that miR‑152 suppressed the ability of ovarian cancer cell proliferation, migration and invasion, and promoted apoptosis through inhibiting ERBB3 in vitro. Therefore, in the present study, miR‑152 was found to be involved in the proliferation and metastasis of ovarian cancer cells through repression of ERBB3 expression. Therefore, miR‑152 may be a potential therapeutic target for the treatment of ovarian cancer.

微小 RNA（miRNAs）通过靶向参与多种生物学过程的靶基因的 3'非翻译区参与转录后调控。据我们所知，miR-152 与卵巢癌中的 ERBB3 之间的关联尚不清楚。在本研究中，观察到卵巢癌中 miR-152 与 ERBB3 呈负相关。荧光素酶报告基因检测结果表明，miR-152 在 SKOV3 和 OVCAR3 卵巢癌细胞中负调控 ERBB3。此外，我们的结果表明，miR-152 通过抑制 ERBB3 在体外抑制卵巢癌细胞增殖、迁移和侵袭，并促进凋亡。因此，在本研究中，发现 miR-152 通过抑制 ERBB3 表达参与卵巢癌细胞的增殖和转移。因此，miR-152 可能是治疗卵巢癌的潜在治疗靶点。