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miR-152-3p 通过靶向 MAP3K2/JNK/c-Jun 通路保护脑缺血再灌注损伤导致的血脑屏障破坏

MicroRNA152-3p Protects Against Ischemia/Reperfusion-Induced Bbb Destruction Possibly Targeting the MAP3K2/JNK/c-Jun Pathway.

机构信息

Department of Neurology, Changzheng Hospital, Naval Medical University, Shanghai, China.

Department of Neurology, 2nd Xiangya Hospital, Central South University, Changsha, Hunan, China.

出版信息

Neurochem Res. 2023 May;48(5):1293-1304. doi: 10.1007/s11064-022-03828-1. Epub 2022 Nov 29.

DOI:10.1007/s11064-022-03828-1
PMID:36445489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10066145/
Abstract

In the current study, we reported that overexpression of miR-152-3p effectively ameliorated neurological deficits and protected blood-brain barrier(BBB) integrity in middle cerebral artery occlusion (MCAO) rats. In an in vitro model, the level of miR-152-3p was significantly decreased in bEnd.3 cells after oxygen-glucose deprivation/reperfusion (OGD/R) insult. miR-152-3p overexpressing bEnd.3 cell monolayers were protected from OGD/R-induced microvascular hyperpermeability. The miR-152-3p-mediated protective effect was associated with lower apoptosis of endothelia by negatively modulating the MAP3K2/JNK/c-Jun pathway.

摘要

在本研究中，我们报道了 miR-152-3p 的过表达可有效改善大脑中动脉闭塞（MCAO）大鼠的神经功能缺损并保护血脑屏障（BBB）的完整性。在体外模型中，缺氧/复氧（OGD/R）损伤后 bEnd.3 细胞中的 miR-152-3p 水平显著降低。过表达 miR-152-3p 的 bEnd.3 细胞单层可防止 OGD/R 诱导的微血管通透性增加。miR-152-3p 介导的保护作用与通过负调控 MAP3K2/JNK/c-Jun 通路降低内皮细胞凋亡有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194e/10066145/b70a7a99770b/11064_2022_3828_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194e/10066145/b70a7a99770b/11064_2022_3828_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194e/10066145/0579cea04160/11064_2022_3828_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194e/10066145/bc4b40a7c1ac/11064_2022_3828_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194e/10066145/eae3d50b777f/11064_2022_3828_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194e/10066145/52a18014ae65/11064_2022_3828_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194e/10066145/595637d638d7/11064_2022_3828_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194e/10066145/8e0f97fde8e8/11064_2022_3828_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194e/10066145/b70a7a99770b/11064_2022_3828_Fig7_HTML.jpg

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