Special Care Medical Center, Navy General Hospital of PLA, Beijing 100048, P.R. China.
Mol Med Rep. 2018 Mar;17(3):4099-4105. doi: 10.3892/mmr.2017.8342. Epub 2017 Dec 22.
Icariside II is a flavonoid extracted from Epimedium that has antioxidant, anti‑inflammatory and antiapoptotic effects. The aim of the present study was to evaluate the effects icariside II on diabetic cardiomyopathy in streptozotocin-induced diabetic rats. Icariside II treatment improved body weight, heart/body weight ratio and fasting blood glucose in diabetic model rats. Icariside II was demonstrated to reduce the expression levels of creatine kinase and lactate dehydrogenase in serum, and to lower cardiac oxidative stress, inflammation and apoptosis levels in diabetic rats. Icariside II treatment induced phosphoinositide 3‑kinase and phosphorylated‑Akt expression, and suppressed inducible nitric oxide synthase (iNOS) and nuclear factor (NF)‑κB protein expression in diabetic rat. Results from the present study suggested that treatment with icariside II improved diabetic cardiomyopathy in streptozotocin‑induced diabetic rats by activating the Akt/NOS/NF‑κB pathway.
二苯乙烯苷是从淫羊藿中提取的一种黄酮类化合物，具有抗氧化、抗炎和抗细胞凋亡作用。本研究旨在评估二苯乙烯苷对链脲佐菌素诱导的糖尿病大鼠糖尿病心肌病的影响。二苯乙烯苷治疗可改善糖尿病模型大鼠的体重、心脏/体重比和空腹血糖。研究表明，二苯乙烯苷可降低血清肌酸激酶和乳酸脱氢酶的表达水平，并降低糖尿病大鼠心脏的氧化应激、炎症和细胞凋亡水平。二苯乙烯苷治疗可诱导磷酸肌醇 3-激酶和磷酸化 Akt 的表达，并抑制诱导型一氧化氮合酶（iNOS）和核因子（NF）-κB 蛋白在糖尿病大鼠中的表达。本研究结果表明，二苯乙烯苷通过激活 Akt/NOS/NF-κB 通路改善了链脲佐菌素诱导的糖尿病大鼠的糖尿病心肌病。
