Instituto Universitario de Bio-Orgánica Antonio González (IUBO AG), Centro de Investigaciones Biomédicas de Canarias (CIBICAN), Universidad de La Laguna (ULL), Avenida Astrofísico Francisco Sánchez 2, 38206 Tenerife, Spain.
Departamento de Química Orgánica, Universidad de La Laguna (ULL), Avenida Astrofísico Francisco Sánchez s/n, 38206 Tenerife, Spain.
Mar Drugs. 2017 Dec 29;16(1):5. doi: 10.3390/md16010005.
Red algae of continue to provide wide structural diversity and complexity of halogenated C acetogenin medium-ring ethers. Here, we described the isolation of three new C acetogenins (-), and one truncated derivative () from collected on the Canary Islands. These compounds are interesting variations on the pinnatifidenyne structure that included the first examples of ethynyl oxirane derivatives (-). The structures were elucidated by extensive study of NMR (Nuclear Magnetic Resonance) data, -based configuration analysis and DFT (Density Functional Theory) calculations. Their antiproliferative activity against six human solid tumor cell lines was evaluated.
红藻继续提供广泛的结构多样性和卤代 C 乙酰氧基中环醚的复杂性。在这里，我们描述了从加那利群岛采集的 中分离出的三种新的 C 乙酰氧基化合物 (-) 和一种截断衍生物 ()。这些化合物是 pinnatifidenyne 结构的有趣变体，包括第一个乙炔基环氧衍生物的例子 (-)。通过对 NMR（核磁共振）数据、基于的构型分析和 DFT（密度泛函理论）计算的广泛研究，阐明了它们的结构。评估了它们对六种人实体瘤细胞系的抗增殖活性。
