角叉菜脂溶性二萜内酯类化合物。

Tetrahydrofuran acetogenins from Laurencia glandulifera.

机构信息

Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.

出版信息

J Nat Prod. 2009 Feb 27;72(2):190-3. doi: 10.1021/np800481w.

DOI:10.1021/np800481w

PMID:19138151

Abstract

Five new C(15) acetogenin en-ynes (1-5) with a rare tetrahydrofuran moiety and a linear biosynthetic precursor (6) were isolated from an organic extract of Laurencia glandulifera, collected from the island of Crete in the south Aegean Sea. The structures of the new natural products, as well as their relative configuration, were established by means of spectroscopic data analysis. The cytotoxicity of the isolated natural products was evaluated against five human tumor cell lines.

摘要

从采集自爱琴海南部克里特岛的软珊瑚 Laurencia glandulifera 的有机提取物中分离得到五个新型 C(15)乙酰氧基烯炔类化合物（1-5），其中含有一个罕见的四氢呋喃部分和一个线性生物合成前体（6）。通过光谱数据分析确定了这些新天然产物的结构及其相对构型。评估了分离得到的天然产物对五种人肿瘤细胞系的细胞毒性。