Kamada Takashi, Phan Chin-Soon, Vairappan Charles S
a Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation , Universiti Malaysia Sabah , Kota Kinabalu 88400 , Malaysia.
J Asian Nat Prod Res. 2019 Mar;21(3):241-247. doi: 10.1080/10286020.2017.1417265. Epub 2017 Dec 27.
Two new halogenated nonterpenoids C-acetogenins, nangallenes A-B (1-2), together with two known halogenated compounds itomanallene A (3) and 2,10-dibromo-3-chloro-α-chamigrene (4), were isolated and identified from the organic extract of the marine red alga Laurencia nangii Masuda collected from the coastal waters in Semporna, Borneo. Their structures were established by means of spectroscopic analysis including IR, high-resolution electrospray ionization mass spectrometry (HRESI-MS), and 1D and 2D NMR techniques. All these metabolites were submitted for the antifungal assay against four species of selected marine fungi. Compounds 1-4 showed potent activity against Haliphthoros sabahensis and Lagenidium thermophilum.
从婆罗洲仙本那沿海水域采集的海洋红藻南氏劳伦藻（Laurencia nangii Masuda）的有机提取物中，分离并鉴定出两种新的卤代非萜类C-产乙酸素，即南加勒烯A-B（1-2），以及两种已知的卤代化合物异托马纳烯A（3）和2,10-二溴-3-氯-α-菖蒲烯（4）。通过红外光谱（IR）、高分辨率电喷雾电离质谱（HRESI-MS）以及一维和二维核磁共振技术等光谱分析手段确定了它们的结构。所有这些代谢产物都被送去针对四种选定的海洋真菌进行抗真菌试验。化合物1-4对萨巴海疫霉（Haliphthoros sabahensis）和嗜热拉根霉（Lagenidium thermophilum）显示出强效活性。
