Aw Alex, Fritz Marshall, Napoline Jonathan W, Pollet Pamela, Liotta Charles L
School of Chemistry & Biochemistry, Georgia Institute of Technology.
School of Chemical & Biomolecular Engineering, Georgia Institute of Technology.
J Vis Exp. 2017 Nov 15(129):56608. doi: 10.3791/56608.
Continuous flow technology has been identified as instrumental for its environmental and economic advantages leveraging superior mixing, heat transfer and cost savings through the "scaling out" strategy as opposed to the traditional "scaling up". Herein, we report the reaction of diphenyldiazomethane with p-nitrobenzoic acid in both batch and flow modes. To effectively transfer the reaction from batch to flow mode, it is essential to first conduct the reaction in batch. As a consequence, the reaction of diphenyldiazomethane was first studied in batch as a function of temperature, reaction time, and concentration to obtain kinetic information and process parameters. The glass flow reactor set-up is described and combines two types of reaction modules with "mixing" and "linear" microstructures. Finally, the reaction of diphenyldiazomethane with p-nitrobenzoic acid was successfully conducted in the flow reactor, with up to 95% conversion of the diphenyldiazomethane in 11 min. This proof of concept reaction aims to provide insight for scientists to consider flow technology's competitiveness, sustainability, and versatility in their research.
连续流动技术因其环境和经济优势而被视为具有重要作用，它通过“扩大规模”策略利用卓越的混合、传热性能并节省成本，这与传统的“扩大体积”不同。在此，我们报告了二苯基重氮甲烷与对硝基苯甲酸在间歇式和流动模式下的反应。为了有效地将反应从间歇式模式转移到流动模式，首先在间歇式模式下进行反应至关重要。因此，首先研究了二苯基重氮甲烷在间歇式模式下作为温度、反应时间和浓度的函数的反应，以获得动力学信息和工艺参数。描述了玻璃流动反应器装置，它结合了两种具有“混合”和“线性”微结构的反应模块。最后，二苯基重氮甲烷与对硝基苯甲酸的反应在流动反应器中成功进行，并在11分钟内实现了高达95%的二苯基重氮甲烷转化率。这个概念验证反应旨在为科学家们在其研究中考虑流动技术的竞争力、可持续性和多功能性提供见解。
