Weissfeld Joel L, Liu Wei, Woods Corinne, Zhang Rongmei, Li Jie, van der Vlugt Theresa H, Slaughter Shelley R
Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD.
Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD.
Menopause. 2018 Jun;25(6):611-614. doi: 10.1097/GME.0000000000001054.
We aimed to provide information through 2015 about use in the United States of estrogen products, including orally and vaginally administered products, in postmenopausal women.
We used prescription claims for US commercial health insurance to calculate, in women 50 years of age or older (n = 12,007,364), the age-standardized and age-specific annual prevalence of estrogen use, by formulation and route of administration, for the period 2006 through 2015.
The age-standardized annual prevalence of a prescription claim for oral estrogens declined over time, from 83 per 1,000 women in 2007 to 42 per 1,000 women in 2015. The age-standardized annual prevalence of a prescription claim for vaginal estrogens peaked in 2011, at 42 per 1,000 women, before declining to 35 per 1,000 women in 2015. The age-standardized annual prevalence of a prescription claim for transdermal estrogen fluctuated between 15 and 17 per 1,000 women. In age groups under 65 years of age, annual prevalence rates for vaginal rings and inserts declined over the latter half of the study period.
Analyses of US prescription claims data between 2006 and 2015 for women 50 years of age or older showed declining use of oral estrogen generally and vaginally administered estrogen products specifically in age groups less than 65 years of age.
我们旨在提供截至2015年美国绝经后女性使用雌激素产品（包括口服和阴道给药产品）的相关信息。
我们利用美国商业健康保险的处方索赔数据，计算了2006年至2015年期间50岁及以上女性（n = 12,007,364）按制剂和给药途径划分的雌激素使用年龄标准化患病率和特定年龄患病率。
口服雌激素处方索赔的年龄标准化年患病率随时间下降，从2007年的每1000名女性83例降至2015年的每1000名女性42例。阴道雌激素处方索赔的年龄标准化年患病率在2011年达到峰值，为每1000名女性42例，随后在2015年降至每1000名女性35例。经皮雌激素处方索赔的年龄标准化年患病率在每1000名女性15至17例之间波动。在65岁以下年龄组中，阴道环和阴道栓剂的年患病率在研究期后半段有所下降。
对2006年至2015年期间50岁及以上女性的美国处方索赔数据进行分析显示，总体上口服雌激素的使用有所下降，尤其是65岁以下年龄组中阴道给药的雌激素产品使用量下降。
