Cesur Müberra Fatma, Durmuş Saliha
Computational Systems Biology Group, Department of Bioengineering, Gebze Technical University, Kocaeli, Turkey.
Methods Mol Biol. 2018;1734:97-112. doi: 10.1007/978-1-4939-7604-1_10.
Pathogen-host interactions (PHIs) underlie the process of infection. The systems biology view of the whole PHI system is superior to the investigation of the pathogen or host separately in understanding the infection mechanisms. Especially, the identification of host-oriented drug targets for the next-generation anti-infection therapeutics requires the properties of the host factors targeted by pathogens. Here, we provide an outline of computational analysis of PHI networks, focusing on the properties of the pathogen-targeted host proteins. We also provide information about the available PHI data and the related Web-based resources.
病原体-宿主相互作用（PHIs）是感染过程的基础。在理解感染机制方面，对整个PHI系统的系统生物学观点优于单独对病原体或宿主的研究。特别是，为新一代抗感染治疗确定以宿主为导向的药物靶点需要了解病原体靶向的宿主因子的特性。在此，我们概述了PHI网络的计算分析，重点关注病原体靶向的宿主蛋白的特性。我们还提供了可用的PHI数据及相关网络资源的信息。
