Ling Kak-Ming, Garratt Luke W, Lassmann Timo, Stick Stephen M, Kicic Anthony
Paediatrics, Medical School, Faculty of Healthy and Medical Science, University of Western Australia, Nedlands, WA, Australia.
Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia.
Front Pharmacol. 2018 Nov 7;9:1270. doi: 10.3389/fphar.2018.01270. eCollection 2018.
Chronic lung disease remains the primary cause of mortality in cystic fibrosis (CF). Growing evidence suggests respiratory viral infections are often more severe in CF compared to healthy peers and contributes to pulmonary exacerbations (PEx) and deterioration of lung function. Rhinovirus is the most prevalent respiratory virus detected, particularly during exacerbations in children with CF <5 years old. However, even though rhinoviral infections are likely to be one of the factors initiating the onset of CF lung disease, there is no effective targeted treatment. A better understanding of the innate immune responses by CF airway epithelial cells, the primary site of infection for viruses, is needed to identify why viral infections are more severe in CF. The aim of this review is to present the clinical impact of virus infection in both young children and adults with CF, focusing on rhinovirus infection. Previous and investigations looking at the mechanisms behind virus infection will also be summarized. The review will finish on the potential of transcriptomics to elucidate the host-pathogen responses by CF airway cells to viral infection and identify novel therapeutic targets.
慢性肺部疾病仍然是囊性纤维化（CF）患者死亡的主要原因。越来越多的证据表明，与健康同龄人相比，CF患者的呼吸道病毒感染往往更为严重，并会导致肺部病情加重（PEx）和肺功能恶化。鼻病毒是检测到的最常见的呼吸道病毒，尤其是在5岁以下CF儿童病情加重期间。然而，尽管鼻病毒感染可能是引发CF肺部疾病的因素之一，但目前尚无有效的靶向治疗方法。为了弄清楚为何病毒感染在CF患者中更为严重，需要更好地了解CF气道上皮细胞（病毒感染的主要部位）的先天免疫反应。本综述的目的是阐述病毒感染对CF患儿和成人的临床影响，重点关注鼻病毒感染。同时，还将总结以往关于病毒感染背后机制的研究。综述将以转录组学在阐明CF气道细胞对病毒感染的宿主-病原体反应及确定新治疗靶点方面的潜力作为结尾。
