伊拉克阿拉伯人的细胞因子基因多态性。
Cytokine gene polymorphisms in Iraqi Arabs.
作者信息
Ad'hiah Ali H, Ahmed Zahra'a A, Al-Naseri Milad A, Salman Ehab D, Al-Saffar Osama B, Ahmed Hiba S, Hussain Talib A, Idan Ekhlass M, Hassan Ibtesam B, Shihab Batool A, Mohammed Lateef O, Al-Nasiri Fatima S
机构信息
Tropical-Biological Research Unit, College of Science, University of Baghdad, Baghdad, Iraq.
Department of Biology, College of Science for Women, University of Baghdad, Baghdad, Iraq.
出版信息
Hum Immunol. 2018 Feb;79(2):91-92. doi: 10.1016/j.humimm.2017.12.009. Epub 2017 Dec 27.
In this report, 224 unrelated healthy Iraqi Arabs (102 males and 122 females) were genotyped for 22 SNPs (single nucleotide polymorphisms) belong to 13 cytokine genes (IL1A, IL1B, IL1RA, IL1R, IL2, IL4, IL4R, IL6, IL10, IL12, IFNG, TNFA and TGFB1). The method of detection was PCR-SSP (polymerase chain reaction-sequence specific primer). The data were presented in terms of allele and genotype frequencies. Two-locus haplotype frequencies were also estimated for some SNPs. Genotype frequencies of detected cytokine gene polymorphisms are available in the Database of Allele Frequencies Net under the AFND number 3422 and the population name "Iraq Arab Cytokine".
在本报告中，对224名无亲缘关系的健康伊拉克阿拉伯人（102名男性和122名女性）进行了基因分型，检测了属于13种细胞因子基因（IL1A、IL1B、IL1RA、IL1R、IL2、IL4、IL4R、IL6、IL10、IL12、IFNG、TNFA和TGFB1）的22个单核苷酸多态性（SNP）。检测方法为聚合酶链反应-序列特异性引物（PCR-SSP）。数据以等位基因和基因型频率表示。还对一些SNP估计了两位点单倍型频率。检测到的细胞因子基因多态性的基因型频率可在等位基因频率网数据库中查询，编号为AFND 3422，群体名称为“伊拉克阿拉伯细胞因子”。
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