Krüppel 样因子 15：支链氨基酸代谢和昼夜节律蛋白节律的调节剂。
Krüppel-like factor 15: Regulator of BCAA metabolism and circadian protein rhythmicity.
机构信息
Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
出版信息
Pharmacol Res. 2018 Apr;130:123-126. doi: 10.1016/j.phrs.2017.12.018. Epub 2017 Dec 27.
Regulation of nutrient intake, utilization, and storage exhibits a circadian rhythmicity that allows organisms to anticipate and adequately respond to changes in the environment across day/night cycles. The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are important modulators of metabolism and metabolic health - for example, their catabolism yields carbon substrates for gluconeogenesis during periods of fasting. Krüppel-like factor 15 (KLF15) has recently emerged as a critical transcriptional regulator of BCAA metabolism, and the absence of this transcription factor contributes to severe pathologies such as Duchenne muscular dystrophy and heart failure. This review highlights KLF15's role as a central regulator of BCAA metabolism during periods of fasting, throughout day/night cycles, and in experimental models of muscle disease.
营养摄入、利用和储存的调节表现出昼夜节律性，使生物体能够预测并充分应对日夜周期中环境的变化。支链氨基酸（BCAAs）亮氨酸、异亮氨酸和缬氨酸是代谢和代谢健康的重要调节剂 - 例如，它们的分解代谢在禁食期间为糖异生提供碳底物。Krüppel 样因子 15（KLF15）最近成为 BCAA 代谢的关键转录调节剂，这种转录因子的缺失导致严重的病理，如杜氏肌营养不良症和心力衰竭。这篇综述强调了 KLF15 在禁食期间、整个日夜周期以及肌肉疾病的实验模型中作为 BCAA 代谢的中央调节剂的作用。
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