Lee Wonhwa, Hwang Mi-Hye, Lee Yuri, Bae Jong-Sup
College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics Based Creative Drug Research Team, Kyungpook National University, Daegu, 41566, Republic of Korea; Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea.
Bacterial Disease Division, Animal and Plant Quarantine Agency, Gimcheon, Gyeongsangbukdo, 39660, Republic of Korea.
Chem Biol Interact. 2018 Feb 1;281:106-110. doi: 10.1016/j.cbi.2017.12.031. Epub 2017 Dec 28.
The aim of this study was to investigate the effects of zingerone (ZGR) on lipopolysaccharide (LPS)-induced liver failure in mice, and to elucidate underlying mechanisms. ZGR is a phenolic alkanone isolated from ginger, and has potential health benefits. Mice were treated intravenously with ZGR at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of alanine transaminase, aspartate transaminase, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression; these effects of LPS were inhibited by ZGR. It also attenuated the LPS-induced activation of myeloid differentiation primary response gene 88 and TLR-associated activator of interferon-dependent signaling pathways of the TLR system. Our results suggest that ZGR protects against LPS-induced liver damage by inhibiting the TLR-mediated inflammatory pathway, indicating its potential to treat liver diseases.
本研究旨在探讨姜辣素（ZGR）对脂多糖（LPS）诱导的小鼠肝衰竭的影响，并阐明其潜在机制。ZGR是一种从生姜中分离出的酚类烷酮，具有潜在的健康益处。在LPS处理12小时后，给小鼠静脉注射ZGR。LPS显著增加死亡率、血清丙氨酸转氨酶、天冬氨酸转氨酶和炎性细胞因子水平以及Toll样受体4（TLR4）蛋白表达；ZGR可抑制LPS的这些作用。它还减弱了LPS诱导的髓样分化初级反应基因88的激活以及TLR系统中TLR相关的干扰素依赖性信号通路的激活。我们的结果表明，ZGR通过抑制TLR介导的炎症途径来保护免受LPS诱导的肝损伤，表明其治疗肝脏疾病的潜力。
