University of Vienna, Department of Pharmacognosy, Althanstrasse 14, 1090 Vienna, Austria.
University of Vienna, Department of Pharmacognosy, Althanstrasse 14, 1090 Vienna, Austria.
Biotechnol Adv. 2018 Nov 1;36(6):1738-1767. doi: 10.1016/j.biotechadv.2017.12.015. Epub 2017 Dec 28.
Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor boosting cytoprotective responses, and many phytochemicals activate Nrf2 signaling. Thus, Nrf2 activation by natural products could presumably alleviate DM. We summarize function, regulation and exogenous activation of Nrf2, as well as diabetes-linked and Nrf2-susceptible forms of cellular stress. The reported amelioration of insulin resistance, β-cell dysfunction and diabetic complications by activated Nrf2 as well as the status quo of Nrf2 in precision medicine for DM are reviewed.
2 型糖尿病（DM）已达到流行程度，需要有效的预防策略。其发病伴随着细胞应激，核因子红细胞 2 相关因子 2（Nrf2）是一种转录因子，可增强细胞保护反应，许多植物化学物质可激活 Nrf2 信号。因此，天然产物对 Nrf2 的激活可能会缓解 DM。我们总结了 Nrf2 的功能、调节和外源性激活，以及与糖尿病相关的和 Nrf2 易感性的细胞应激形式。综述了激活的 Nrf2 对胰岛素抵抗、β细胞功能障碍和糖尿病并发症的改善作用，以及 Nrf2 在 DM 精准医学中的现状。
