Bitarafan Fatemeh, Khodaeian Mehrnoosh, Tabatabaei-Malazy Ozra, Amoli Mahsa M
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran -
Minerva Endocrinol. 2019 Sep;44(3):310-325. doi: 10.23736/S0391-1977.17.02632-3. Epub 2017 May 26.
Oxidative stress has a key role in pathophysiology of type 2 diabetes mellitus (T2DM) and its complications as a most common health problem. Due to controversial evidence regarding the association between antioxidants' gene varients and T2DM, our aim was a systematic review of the current meta-analyses.
All meta-analysis' studies which assessed the association of single nucleotide polymorphisms of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPX), glutathione S transferase (GST), nitric oxide synthase (NOS) and nicotinamide adenine dinucleotide phosphate oxidase (NOX) with T2DM and its complications were systematically extracted from PubMed, Scopus and Web of Science databases up to January 2016. Results are reported according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA).
Among 131 articles recorded in initial search, 19 studies were in the topic just for eNOS (endothelial NOS), NOX, GST and SOD gene variants. G894T, 4b/a and T-786C variants (eNOS) were associated with DN (diabetic nephropathy). However no association between 4b/a variant and DR (diabetic retinopathy) was observed. Separate or combination of GSTM1 and GSTT1 null genotypes (GST gene) were associated with T2DM. GSTM1 and combination of GSTM1/GSTT1 null genotypes were associated with DN. Significant association between C242T variant (NOX) and T2DM or DN, and non-significant association with carotid atherosclerosis were seen. C allele of C47T variant (SOD) was protective against DN, DR and microvascular complications of diabetes.
Finding gene polymorphisms involved in diabetes and its complications might be helpful in discovering new therapeutic approaches, as well as prevention which is currently as a main focus in personalized medicine.
氧化应激在2型糖尿病（T2DM）及其并发症的病理生理学中起着关键作用，而T2DM是最常见的健康问题。由于抗氧化剂基因变异与T2DM之间关联的证据存在争议，我们的目的是对当前的荟萃分析进行系统综述。
从PubMed、Scopus和Web of Science数据库中系统提取了截至2016年1月所有评估超氧化物歧化酶（SOD）、过氧化氢酶、谷胱甘肽过氧化物酶（GPX）、谷胱甘肽S转移酶（GST）、一氧化氮合酶（NOS）和烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NOX）的单核苷酸多态性与T2DM及其并发症之间关联的荟萃分析研究。结果根据系统评价和荟萃分析的首选报告项目（PRISMA）进行报告。
在初步检索记录的131篇文章中，有19项研究涉及内皮型一氧化氮合酶（eNOS）、NOX、GST和SOD基因变异的主题。G894T、4b/a和T-786C变异（eNOS）与糖尿病肾病（DN）相关。然而，未观察到4b/a变异与糖尿病视网膜病变（DR）之间存在关联。GSTM1和GSTT1无效基因型（GST基因）单独或联合与T2DM相关。GSTM1以及GSTM1/GSTT1无效基因型联合与DN相关。观察到C242T变异（NOX）与T2DM或DN之间存在显著关联，与颈动脉粥样硬化之间无显著关联。C47T变异（SOD）的C等位基因对DN、DR和糖尿病微血管并发症具有保护作用。
发现参与糖尿病及其并发症的基因多态性可能有助于发现新的治疗方法以及预防措施，而预防目前是个性化医疗的主要重点。
