Faridi Shahbaz Habib, Siddiqui Bushra, Ahmad Syed Shamshad, Aslam Mohammad
Department of Surgery, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Department of Pathology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
J Coll Physicians Surg Pak. 2018 Jan;28(1):69-71. doi: 10.29271/jcpsp.2018.01.69.
Phyllodes tumours are uncommon breast tumours which account for less than 1% of all breast neoplasms. High-grade malignant phyllodes tumour is a very rare but aggressive breast malignancy and forms approximately 15-30% of all phyllodes tumours. The transformation of a benign fibroadenoma into a malignant phyllodes tumour in a teenaged female is even rarer. We report here an interesting case of malignant phyllodes tumour in a 14-year female patient who was operated twice previously with the diagnosis of complex fibroadenoma in the same breast. There was a large tumour involving whole of the breast and infiltrating the skin. The patient was operated and total mastectomy was done. Diagnosis was confirmed after histopathological examination and immunohistochemistry of the resected specimen. Patient received adjuvant radiotherapy and there was no recurrence on 6-month follow-up. Owing to the rare occurrence of malignant phyllodes tumour in this age group along with previous operations for complex fibroadenoma, this case is being reported here.
叶状肿瘤是一种罕见的乳腺肿瘤，占所有乳腺肿瘤的比例不到1%。高级别恶性叶状肿瘤是一种非常罕见但侵袭性强的乳腺恶性肿瘤，约占所有叶状肿瘤的15% - 30%。青少年女性的良性纤维腺瘤转变为恶性叶状肿瘤的情况更为罕见。我们在此报告一例有趣的病例，一名14岁女性患者患有恶性叶状肿瘤，她此前曾因同一乳房的复杂性纤维腺瘤接受过两次手术。有一个巨大的肿瘤累及整个乳房并侵犯皮肤。患者接受了手术，进行了全乳切除术。切除标本经组织病理学检查和免疫组化后确诊。患者接受了辅助放疗，6个月随访无复发。鉴于该年龄组恶性叶状肿瘤的罕见性以及此前因复杂性纤维腺瘤进行的手术，特此报告此病例。
