Winter C C, Trepashko D W
Division of Urology, Ohio State University Medical Center, Columbus.
Urology. 1989 Apr;33(4):320-1. doi: 10.1016/0090-4295(89)90276-8.
A rare case of solitary metastasis to subcutaneous tissue from choriocarcinoma of the testis which was predominantly seminoma is reported. The propensity for vascular route of metastasis of this tumor type producing the patient's clinical picture is presented. The human beta chorionic gonadotropin tumor marker elevation to 4,200 units preoperatively fell to normal two weeks postoperatively, suggesting a solitary metastatic site with total tumor extirpation. Nevertheless, it seemed prudent to give chemotherapy because the nature of the metastatic route suggested other microscopic sites of metastasis. The prognosis of this highly malignant neoplasm, while poorest of the array of testis tumors, has improved dramatically with the advent of effective chemotherapy.
报告了一例罕见的以精原细胞瘤为主的睾丸绒毛膜癌皮下组织孤立转移病例。介绍了这种肿瘤类型通过血管转移途径导致患者临床表现的倾向。术前人β绒毛膜促性腺激素肿瘤标志物升高至4200单位,术后两周降至正常,提示为孤立转移灶且肿瘤已完全切除。然而,鉴于转移途径的性质提示可能存在其他微小转移部位,给予化疗似乎是谨慎的做法。这种高度恶性肿瘤的预后虽然在睾丸肿瘤中是最差的,但随着有效化疗的出现已显著改善。