Shimizu S, Nagata Y, Han-yaku H
Division of Dermatology, Ogikubo Hospital, Tokyo, Japan.
Am J Dermatopathol. 1996 Dec;18(6):633-6. doi: 10.1097/00000372-199612000-00016.
Choriocarcinoma is a malignant growth of trophoblastic cells characterized by secretion of human chorionic gonadotropin. Choriocarcinoma usually arises from fetal trophoblasts and rarely arises from germ cells in the testis or ovary or derives from dedifferentiation of other carcinomas. Skin metastasis of choriocarcinoma is rare: only seven cases have been reported in the English and Japanese literature. We report the case of a 22-year-old Japanese man with pure choriocarcinoma of the testis who developed skin metastases that presented as multiple reddish nodules. Microscopic examination of both the primary lesion of the testis and the cutaneous metastasis demonstrated the typical histologic features of pure choriocarcinoma. The patient died 3 months after the initial onset of skin metastasis. Review of the literature indicates that skin metastasis of choriocarcinoma usually occurs as a nodular lesion with the histologically typical feature of the primary disease and signals of poor prognosis.
绒毛膜癌是一种滋养层细胞的恶性肿瘤，其特征是分泌人绒毛膜促性腺激素。绒毛膜癌通常起源于胎儿滋养层细胞，很少起源于睾丸或卵巢的生殖细胞，或由其他癌的去分化产生。绒毛膜癌的皮肤转移罕见：英文和日文文献中仅报道过7例。我们报告一例22岁日本男性，患有睾丸纯绒毛膜癌，发生了皮肤转移，表现为多个红色结节。对睾丸原发性病变和皮肤转移灶的显微镜检查均显示出纯绒毛膜癌的典型组织学特征。患者在皮肤转移初次出现后3个月死亡。文献回顾表明，绒毛膜癌的皮肤转移通常表现为结节性病变，具有原发性疾病的典型组织学特征，提示预后不良。
