Requena L, Sánchez M, Aguilar A, Sánchez Yus E
Departamento de Dermatología, Hospital Universitario San Carlos, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
J Dermatol Surg Oncol. 1991 May;17(5):466-70. doi: 10.1111/j.1524-4725.1991.tb03984.x.
A case of choriocarcinoma of the testis metastatic to the skin is reported. In this case report the primary tumor was first diagnosed by the histopathologic findings in the cutaneous biopsy of a single nodule that appeared on the chest, with both syncytiotrophoblastic and cytotrophoblastic cells in the metastatic solid tumor islands. Using peroxidase-antiperoxidase techniques, beta-human chorionic gonadotropin (beta-HCG) was positive within the cytoplasm of syncytiotrophoblastic cells. The patient was treated with orchiectomy, chemotherapy, and radiotherapy. With these measures there was a decrease of chorionic gonadotropin serum levels to normal limits and 2 years after this treatment there is no evidence of recurrence.
报告了一例睾丸绒毛膜癌转移至皮肤的病例。在此病例报告中,原发性肿瘤首先通过对胸部出现的单个结节进行皮肤活检的组织病理学检查结果得以诊断,转移性实体瘤岛中同时存在合体滋养层细胞和细胞滋养层细胞。采用过氧化物酶 - 抗过氧化物酶技术,在合体滋养层细胞的细胞质内β - 人绒毛膜促性腺激素(β - HCG)呈阳性。该患者接受了睾丸切除术、化疗和放疗。通过这些措施,绒毛膜促性腺激素血清水平降至正常范围,且在该治疗后2年无复发迹象。